The Homeodomain-interacting protein kinase (Hipk) family of proteins plays diverse, and at
times conflicting, biological roles in normal development and disease. In this review we will …

Although lineage reprogramming from one cell type to another is becoming a breakthrough
technology for cell-based therapy, several limitations remain to be overcome, including the …

The diverse subtypes of excitatory neurons that populate the neocortex are born from apical
progenitors located in the ventricular zone. During corticogenesis, apical progenitors …

Tissue regeneration relies on resident stem cells (SCs), whose activity and lineage choices
are influenced by the microenvironment. Exploiting the synchronized, cyclical bouts of tissue …

Throughout the past decade, studying ancient genomes has provided unique insights into
human prehistory, and differences between modern humans and other branches like …

Polycomb repressive complex (PRC) 1 maintains developmental genes in a poised state
through monoubiquitination (Ub) of histone H2A. Although Ub-independent functions of …

Neurodevelopmental disorders are thought to arise from interrupted development of the
brain at an early age. Genome-wide association studies (GWAS) have identified hundreds of …

Many infertile men are the victims of spermatogenesis disorder. However, conventional
clinical test could not provide efficient information on the causes of spermatogenesis …

The hair follicle is a complex structure that goes through a cyclic period of growth (anagen),
regression (catagen), and rest (telogen) under the regulation of several signaling pathways …

Generation of neurons in the embryonic neocortex is a balanced process of proliferation and
differentiation of neuronal progenitor cells. Canonical Wnt signalling is crucial for expansion …