[HTML][HTML] Lung structure and the intrinsic challenges of gas exchange

CCW Hsia, DM Hyde, ER Weibel - Comprehensive physiology, 2016 - ncbi.nlm.nih.gov
Structural and functional complexities of the mammalian lung evolved to meet a unique set
of challenges, namely, the provision of efficient delivery of inspired air to all lung units within …

Phenotypic plasticity and genetic adaptation to high-altitude hypoxia in vertebrates

JF Storz, GR Scott, ZA Cheviron - Journal of Experimental …, 2010 - journals.biologists.com
High-altitude environments provide ideal testing grounds for investigations of mechanism
and process in physiological adaptation. In vertebrates, much of our understanding of the …

Developmental functional adaptation to high altitude

AR Frisancho - American Journal of Human Biology, 2013 - Wiley Online Library
Various approaches have been used to understand the origins of the functional traits that
characterize the Andean high‐altitude native. Based on the conceptual framework of …

[HTML][HTML] The two-hour marathon: who and when?

MJ Joyner, JR Ruiz, A Lucia - Journal of Applied …, 2011 - journals.physiology.org
In this Viewpoint we ask if information about the physiology, genetics, and empirical history
of elite endurance performance can provide insight into the question of “who” will break the …

Rat lungs show a biphasic formation of new alveoli during postnatal development

SA Tschanz, LA Salm, M Roth-Kleiner… - Journal of applied …, 2014 - journals.physiology.org
Roughly 90% of the gas-exchange surface is formed by alveolarization of the lungs. To the
best of our knowledge, the formation of new alveoli has been followed in rats only by means …

Control of breathing and the circulation in high-altitude mammals and birds

CM Ivy, GR Scott - Comparative Biochemistry and Physiology Part A …, 2015 - Elsevier
Hypoxia is an unremitting stressor at high altitudes that places a premium on oxygen
transport by the respiratory and cardiovascular systems. Phenotypic plasticity and genotypic …

High-altitude exposure of three weeks duration increases lung diffusing capacity in humans

P Agostoni, ER Swenson, M Bussotti… - Journal of applied …, 2011 - journals.physiology.org
Background: high-altitude adaptation leads to progressive increase in arterial PaO2. In
addition to increased ventilation, better arterial oxygenation may reflect improvements in …

Differences in Hematological Traits between High- and Low-Altitude Lizards (Genus Phrynocephalus)

S Lu, Y Xin, X Tang, F Yue, H Wang, Y Bai, Y Niu… - PLoS …, 2015 - journals.plos.org
Phrynocephalus erythrurus (Lacertilia: Agamidae) is considered to be the highest living
reptile in the world (about 4500-5000 m above sea level), whereas Phrynocephalus …

Larger FVC and FEV1 among Tibetans compared to Han born and raised at high altitude

CA Weitz, RM Garruto, CT Chin - American Journal of Physical …, 2016 - Wiley Online Library
Objectives This study compares forced vital capacity (FVC) and Forced Expiratory Volume at
1 Second (FEV1) of Tibetans with those of Han who were born and raised at high altitude …

Development and remodeling of the vertebrate blood‐gas barrier

A Makanya, A Anagnostopoulou… - BioMed research …, 2013 - Wiley Online Library
During vertebrate development, the lung inaugurates as an endodermal bud from the
primitive foregut. Dichotomous subdivision of the bud results in arborizing airways that form …