Immune system abnormalities in schizophrenia: an integrative view and translational perspectives

EA Ermakov, MM Melamud, VN Buneva… - Frontiers in …, 2022 - frontiersin.org
The immune system is generally known to be the primary defense mechanism against
pathogens. Any pathological conditions are reflected in anomalies in the immune system …

Immunoglobulins with non-canonical functions in inflammatory and autoimmune disease states

EA Ermakov, GA Nevinsky, VN Buneva - International journal of molecular …, 2020 - mdpi.com
Immunoglobulins are known to combine various effector mechanisms of the adaptive and
the innate immune system. Classical immunoglobulin functions are associated with antigen …

Neuroimmune transcriptome changes in patient brains of psychiatric and neurological disorders

Y Chen, J Dai, L Tang, T Mikhailova, Q Liang, M Li… - Molecular …, 2023 - nature.com
Neuroinflammation has been implicated in multiple brain disorders but the extent and the
magnitude of change in immune-related genes (IRGs) across distinct brain disorders has not …

Natural IgG against S-protein and RBD of SARS-CoV-2 do not bind and hydrolyze DNA and are not autoimmune

AM Timofeeva, SE Sedykh, EA Ermakov… - International Journal of …, 2022 - mdpi.com
Since the onset of the COVID-19 pandemic, numerous publications have appeared
describing autoimmune pathologies developing after a coronavirus infection, with several …

Catalytic antibodies in bipolar disorder: serum IgGs hydrolyze myelin basic protein

DA Kamaeva, LP Smirnova, SN Vasilieva… - International Journal of …, 2022 - mdpi.com
The pathogenesis of bipolar affective disorder is associated with immunological imbalances,
a general pro-inflammatory status, neuroinflammation, and impaired white matter integrity …

Some structural features of the peptide profile of myelin basic protein-hydrolyzing antibodies in schizophrenic patients

M Zavialova, D Kamaeva, L Kazieva, VS Skvortsov… - PeerJ, 2023 - peerj.com
The antibodies of schizophrenic patients that hydrolyze myelin basic protein (MBP) have
been actively studied recently, but the mechanism of the catalytic properties of …

Igg‐Dependent Hydrolysis of Myelin Basic Protein of Patients with Different Courses of Schizophrenia

DA Parshukova, LP Smirnova… - Journal of …, 2020 - Wiley Online Library
The level hydrolysis of myelin basic protein (MBP) by IgG in patients with schizophrenia was
studied depending on the clinical features and course of the disease. The patients were …

Natural catalytic IgGs hydrolyzing histones in schizophrenia: Are they the link between humoral immunity and inflammation?

EA Ermakov, DA Parshukova, GA Nevinsky… - International journal of …, 2020 - mdpi.com
Schizophrenia is known to be accompanied not only with an imbalance in the
neurotransmitter systems but also with immune system dysregulation and chronic low-grade …

Antigenic targets of patient and maternal autoantibodies in autism spectrum disorder

R Mazón-Cabrera, P Vandormael… - Frontiers in …, 2019 - frontiersin.org
Autism spectrum disorder (ASD) is a neurodevelopmental disorder whose behavioral
symptoms become apparent in early childhood. The underlying pathophysiological …

IgG‐Dependent Dismutation of Superoxide in Patients with Different Types of Multiple Sclerosis and Healthy Subjects

LP Smirnova, IA Mednova, NM Krotenko… - Oxidative medicine …, 2020 - Wiley Online Library
This work is the first to demonstrate that class G immunoglobulins (IgGs) in patients with
multiple sclerosis and healthy individuals have the ability to catalyze the dismutation …