It is widely believed that HDL functions to transport cholesterol from peripheral cells to the
liver by reverse cholesterol transport, a pathway that may protect against atherosclerosis by …

This article reviews the current status of our knowledge of lipoproteins, nutrition, and
coronary heart disease (CHD). Special emphasis is placed on CHD risk assessment, dietary …

Tangier disease, a condition characterized by low levels of high density lipoprotein and
cholesterol accumulation in macrophages, is caused by mutations in the ATP-binding …

Approximately 50 mutations and many single nucleotide polymorphisms have been
described in the ABCA1 gene, with mutations leading to Tangier disease and familial …

Tangier disease is an autosomal recessive genetic disorder characterized by a severe high-
density lipoprotein (HDL) deficiency, sterol deposition in tissue macrophages, and prevalent …

The human ABCG1 gene encodes a member of the ATP-binding cassette (ABC) superfamily
of transporter proteins and is highly induced when macrophages are incubated with …

We and others have recently identified mutations in the ABCA1 gene as the underlying
cause of Tangier disease (TD) and of a dominantly inherited form of familial …

Identification of mutations in the ABCA1 transporter (ABCA1) as the genetic defect in Tangier
disease has generated interest in modulating atherogenic risk by enhancing ABCA1 gene …

The discovery of the ABCA1 lipid transporter has generated interest in modulating human
plasma HDL levels and atherogenic risk by enhancing ABCA1 gene expression. To …

Homozygosity for mutations in ABC transporter A1 (ABCA1) causes Tangier disease, a rare
HDL-deficiency syndrome. Whether heterozygosity for genetic variation in ABCA1 also …