Extrachromosomal circular DNA: a new target in cancer
P Wu, Y Liu, R Zhou, L Liu, H Zeng, F Xiong… - Frontiers in …, 2022 - frontiersin.org
Genomic instability and amplification are intrinsically important traits determining the
development and heterogeneity of tumors. The role of extrachromosomal circular DNA …
development and heterogeneity of tumors. The role of extrachromosomal circular DNA …
Antimalarial resistance risk in Mozambique detected by a novel quadruplex droplet digital PCR assay
N Brown, C da Silva, C Webb, D Matias… - Antimicrobial Agents …, 2024 - Am Soc Microbiol
While the Plasmodium falciparum malaria parasite continues to cause severe disease
globally, Mozambique is disproportionally represented in malaria case totals. Acquisition of …
globally, Mozambique is disproportionally represented in malaria case totals. Acquisition of …
Replication stress increases de novo CNVs across the malaria parasite genome
N Brown, A Luniewski, X Yu, M Warthan, S Liu… - bioRxiv, 2024 - biorxiv.org
Changes in the copy number of large genomic regions, termed copy number variations
(CNVs), contribute to important phenotypes in many organisms. CNVs are readily identified …
(CNVs), contribute to important phenotypes in many organisms. CNVs are readily identified …
[HTML][HTML] Antigenic diversity in malaria parasites is maintained on extrachromosomal DNA
Sequence variation among antigenic var genes enables Plasmodium falciparum malaria
parasites to evade host immunity. Using long sequence reads from haploid clones from a …
parasites to evade host immunity. Using long sequence reads from haploid clones from a …
Single-cell sequencing of the small and AT-skewed genome of malaria parasites
S Liu, AC Huckaby, AC Brown, CC Moore, I Burbulis… - Genome Medicine, 2021 - Springer
Single-cell genomics is a rapidly advancing field; however, most techniques are designed
for mammalian cells. We present a single-cell sequencing pipeline for an intracellular …
for mammalian cells. We present a single-cell sequencing pipeline for an intracellular …
[HTML][HTML] Direct long read visualization reveals metabolic interplay between two antimalarial drug targets
Increases in the copy number of large genomic regions, termed genome amplification, are
an important adaptive strategy for malaria parasites. Numerous amplifications across the …
an important adaptive strategy for malaria parasites. Numerous amplifications across the …
[PDF][PDF] Expansion of GTP cyclohydrolase I copy number in malaria parasites resistant to a pyrimidine biosynthesis inhibitor
Changes in the copy number of large genomic regions, termed copy number variations or
CNVs, 13 are an important adaptive strategy for malaria parasites. Numerous CNVs across …
CNVs, 13 are an important adaptive strategy for malaria parasites. Numerous CNVs across …