[HTML][HTML] Primary neural degeneration in the human cochlea: evidence for hidden hearing loss in the aging ear
PZ Wu, LD Liberman, K Bennett, V De Gruttola… - Neuroscience, 2019 - Elsevier
The noise-induced and age-related loss of synaptic connections between auditory-nerve
fibers and cochlear hair cells is well-established from histopathology in several mammalian …
fibers and cochlear hair cells is well-established from histopathology in several mammalian …
Targeted delivery of brain-derived neurotrophic factor for the treatment of blindness and deafness
I Khalin, R Alyautdin, G Kocherga… - International journal of …, 2015 - Taylor & Francis
Neurodegenerative causes of blindness and deafness possess a major challenge in their
clinical management as proper treatment guidelines have not yet been found. Brain-derived …
clinical management as proper treatment guidelines have not yet been found. Brain-derived …
Auditory-nerve responses to varied inter-phase gap and phase duration of the electric pulse stimulus as predictors for neuronal degeneration
After severe hair cell loss, secondary degeneration of spiral ganglion cells (SGCs) is
observed—a gradual process that spans years in humans but only takes weeks in guinea …
observed—a gradual process that spans years in humans but only takes weeks in guinea …
Early phase trials of novel hearing therapeutics: Avenues and opportunities
AGM Schilder, MP Su, R Mandavia, CR Anderson… - Hearing Research, 2019 - Elsevier
Novel hearing therapeutics are rapidly progressing along the innovation pathway and into
the clinical trial domain. Because these trials are new to the hearing community, they come …
the clinical trial domain. Because these trials are new to the hearing community, they come …
Temporary neurotrophin treatment prevents deafness-induced auditory nerve degeneration and preserves function
After substantial loss of cochlear hair cells, exogenous neurotrophins prevent degeneration
of the auditory nerve. Because cochlear implantation, the current therapy for profound …
of the auditory nerve. Because cochlear implantation, the current therapy for profound …
[HTML][HTML] BDNF-mediated preservation of spiral ganglion cell peripheral processes and axons in comparison to that of their cell bodies
Abstract Treatment with neurotrophins prevents degeneration of spiral ganglion cells (SGCs)
after severe hair cell loss. In a previous study we demonstrated a long-lasting effect with …
after severe hair cell loss. In a previous study we demonstrated a long-lasting effect with …
Bdnf outperforms trkb agonist 7, 8, 3′-thf in preserving the auditory nerve in deafened guinea pigs
In deaf subjects using a cochlear implant (CI) for hearing restoration, the auditory nerve is
subject to degeneration, which may negatively impact CI effectiveness. This nerve …
subject to degeneration, which may negatively impact CI effectiveness. This nerve …
Selective hair cell ablation and noise exposure lead to different patterns of changes in the cochlea and the cochlear nucleus
T Kurioka, MY Lee, AN Heeringa, LA Beyer… - Neuroscience, 2016 - Elsevier
In experimental animal models of auditory hair cell (HC) loss, insults such as noise or
ototoxic drugs often lead to secondary changes or degeneration in non-sensory cells and …
ototoxic drugs often lead to secondary changes or degeneration in non-sensory cells and …
Postnatal expression of neurotrophic factors accessible to spiral ganglion neurons in the auditory system of adult hearing and deafened rats
EM Bailey, SH Green - Journal of Neuroscience, 2014 - Soc Neuroscience
Spiral ganglion neurons (SGNs) receive input from cochlear hair cells and project from the
cochlea to the cochlear nucleus. After destruction of hair cells with aminoglycoside …
cochlea to the cochlear nucleus. After destruction of hair cells with aminoglycoside …
Recovery characteristics of the electrically stimulated auditory nerve in deafened guinea pigs: Relation to neuronal status
Successful cochlear implant performance requires adequate responsiveness of the auditory
nerve to prolonged pulsatile electrical stimulation. Degeneration of the auditory nerve as a …
nerve to prolonged pulsatile electrical stimulation. Degeneration of the auditory nerve as a …