Vaccination is the most effective method of disease prevention and control. Many viruses
and bacteria that once caused catastrophic pandemics (eg, smallpox, poliomyelitis …

New approaches aimed at identifying patient-specific drug targets and addressing unmet
clinical needs in the framework of precision medicine are a strong motivation for researchers …

Seasonal and pandemic influenza outbreaks present severe health and economic burdens.
To overcome limitations on influenza vaccines' availability and effectiveness, researchers …

ABSTRACT BACKGROUND Vaccines based on virus‐like particles (VLPs) are an
alternative to inactivated viral vaccines that combine good safety profiles with strong …

The use of non-standard culture conditions has proven efficient to increase cell performance
and recombinant protein production in different cell hosts. However, the establishment of …

Vaccination remains the most effective available tool for preventing influenza infection,
which affects millions of people annually. The virus is constantly mutating, requiring annual …

The nature of enveloped virus-like particles (VLPs) has triggered high interest in their
application to different research fields, including vaccine development. The baculovirus …

Spotted fever group rickettsiae (SFGR) are obligate intracellular bacteria that cause spotted
fever. The limitations of gene manipulation pose great challenges to studying the infection …

Virus‐like particles (VLPs) are becoming established as vaccines, in particular for influenza
pandemics, increasing the interest in the development of VLPs manufacturing bioprocess …

Insect cells have long been the main expression host of many virus-like particles (VLP).
VLPs resemble the respective viruses but are non-infectious. They are important in vaccine …