Abstract The Human Developmental Cell Atlas (HDCA) initiative, which is part of the Human
Cell Atlas, aims to create a comprehensive reference map of cells during development. This …

The development of the vertebrate eyes is a complex process starting from anterior-posterior
and dorso-ventral patterning of the anterior neural tube, resulting in the formation of the eye …

Human organoids recapitulating the cell-type diversity and function of their target organ are
valuable for basic and translational research. We developed light-sensitive human retinal …

During embryogenesis, optic vesicles develop from the diencephalon via a multistep
process of organogenesis. Using induced pluripotent stem cell (iPSC)-derived human brain …

The emergence of the three germ layers and the lineage-specific precursor cells
orchestrating organogenesis represent fundamental milestones during early embryonic …

Retinoblastoma is a childhood cancer of the developing retina that initiates with biallelic
inactivation of the RB1 gene. Children with germline mutations in RB1 have a high …

Retinoblastoma is the most frequent intraocular malignancy in children, originating from a
maturing cone precursor in the developing retina. Little is known on the molecular basis …

We previously used single-cell transcriptomic analysis to characterize human fetal retinal
development and assessed the degree to which retinal organoids recapitulate normal …

The vertebrate brain emerged more than~ 500 million years ago in common evolutionary
ancestors. To systematically trace its cellular and molecular origins, we established a …

Organoids generated from human pluripotent stem cells provide experimental systems to
study development and disease, but quantitative measurements across different spatial …