Advancement in exosome isolation and label-free detection towards clinical diagnosis

Y Zhou, H Liu, H Chen - TrAC Trends in Analytical Chemistry, 2024 - Elsevier
Studies have demonstrated the promise of exosomes as diagnostic biomarkers and
therapeutic targets for disease diagnosis, treatment, and prognostic assessment. To facilitate …

Shedding Light on Cellular Secrets: A Review of Advanced Optical Biosensing Techniques for Detecting Extracellular Vesicles with a Special Focus on Cancer …

BN Küçük, EG Yilmaz, Y Aslan… - ACS Applied Bio …, 2024 - ACS Publications
In the relentless pursuit of innovative diagnostic tools for cancer, this review illuminates the
cutting-edge realm of extracellular vesicles (EVs) and their biomolecular cargo detection …

Dual-aptamer recognition of DNA Logic Gate Sensor-based specific exosomal proteins for ovarian Cancer diagnosis

M Zhao, Q Li, Y Zhao, H Zhou, Y Yan, RM Kong… - ACS …, 2024 - ACS Publications
Clinical diagnosis of ovarian cancer lacks high accuracy due to the weak selection of
specific biomarkers along with the circumstance biomarkers localization. Clustering analysis …

CRISPR/Cas13a‐Based MicroRNA detection in tumor‐derived extracellular vesicles

JS Hong, T Son, CM Castro, H Im - Advanced Science, 2023 - Wiley Online Library
MicroRNAs (miRNAs) in extracellular vesicles (EVs) play essential roles in cancer initiation
and progression. Quantitative measurements of EV miRNAs are critical for cancer diagnosis …

A homogeneous electrochemical sensing platform based on DNAzyme walker for accurate detection of breast cancer exosomes

M Zhang, T Zhang, W Mei, H Wang, Q Wang… - Sensors and Actuators B …, 2024 - Elsevier
Exosomes generated from tumors contain a range of bioactive molecules, making them
attractive and trustworthy non-invasive biomarkers for prognostic monitoring and adjuvant …

A “dual-key-and-lock” DNA nanodevice enables spatially controlled multimodal imaging and combined cancer therapy

S Yue, J Zhan, X Xu, J Xu, S Bi, JJ Zhu - Chemical Science, 2024 - pubs.rsc.org
DNA-based theragnostic platforms have attracted more and more attention, while their
applications are still impeded by nonspecific interference and insufficient therapeutic …

Interpretable Machine Learning-Aided Optical Deciphering of Serum Exosomes for Early Detection, Staging, and Subtyping of Lung Cancer

Y Liu, C Cai, W Xu, B Li, L Wang, Y Peng, Y Yu… - Analytical …, 2024 - ACS Publications
Lung cancer (LC) is the leading cause of cancer-related mortality worldwide, underscoring
an urgent need for strategies that enable early detection and phenotypic classification. Here …

Portable Monitoring System for Assessing Therapeutic Efficacy in HER2‐Overexpressing Breast Cancer: One‐Step Simultaneous Detection of Cancer‐Derived …

R Kim, B Mun, J Lim, H Jeong, HY Son… - Advanced Functional …, 2024 - Wiley Online Library
Abstract Point‐of‐care (POC) monitoring of patient condition is crucial for effective cancer
treatment and prognosis. This can be achieved non‐invasively by analyzing exosomes in …

Digital Profiling of Tumor Extracellular Vesicle-Associated RNAs Directly from Unprocessed Blood Plasma

EM Clarissa, S Kumar, J Park, M Karmacharya, IJ Oh… - ACS …, 2024 - ACS Publications
Tumor-derived extracellular vesicle (tEV)-associated RNAs hold promise as diagnostic
biomarkers, but their clinical use is hindered by the rarity of tEVs among nontumor EVs …

Advancements in Exosome Proteins for Breast Cancer Diagnosis and Detection: With a Focus on Nanotechnology

MJ Saadh, AMA Al-Rihaymee, M Kaur, A Kumar… - AAPS …, 2024 - Springer
Breast cancer, a leading cause of mortality among women, has been recognized as
requiring improved diagnostic methods. Exosome proteins, found in small extracellular …