Abstract The coronavirus disease 2019 (COVID-19) pandemic is having a catastrophic
impact on human health 1. Widespread community transmission has triggered stringent …

Approaches based on animal and two-dimensional (2D) cell culture models cannot ensure
reliable results in modeling novel pathogens or in drug testing in the short term; therefore …

Small-molecule antivirals can be used as chemical probes to stabilize transitory
conformational stages of viral target proteins, facilitating structural analyses. Here, we …

Measles cases have surged pre-COVID-19 and the pandemic has aggravated the problem.
Most measles-associated morbidity and mortality arises from destruction of pre-existing …

Nipah virus (NiV) is a bat-borne, zoonotic RNA virus that is highly pathogenic in humans.
The NiV polymerase, which mediates viral genome replication and mRNA transcription, is a …

Morbilliviruses are among the most contagious viral pathogens of mammals. Although
previous metagenomic surveys have identified morbillivirus sequences in bats, full-length …

Batborne henipaviruses, such as Nipah and Hendra viruses, represent a major threat to
global health due to their propensity for spillover, severe pathogenicity, and high mortality …

Nipah virus (NiV) is a non-segmented, negative-strand (NNS) RNA virus, belonging to
Paramyxoviridae. The RNA polymerase complex, composed of large (L) protein and …

Infectious diseases worldwide affect human health and have important societal impacts. A
better understanding of infectious diseases is urgently needed. In vitro and in vivo infection …

Particles of many paramyxoviruses include small amounts of proteins with a molecular
weight of about 20 kDa. These proteins, termed “C”, are basic, have low amino acid …