Cell types to order: temporal specification of CNS stem cells
H Okano, S Temple - Current opinion in neurobiology, 2009 - Elsevier
Spatial and temporal specification of neural progenitor cells is integral to their production of
a wide variety of central nervous system (CNS) cells. For a given region, cells arise on a …
a wide variety of central nervous system (CNS) cells. For a given region, cells arise on a …
Self-formation of layered neural structures in three-dimensional culture of ES cells
M Eiraku, Y Sasai - Current opinion in neurobiology, 2012 - Elsevier
In vitro neural differentiation culture of embryonic stem cells (ESCs) provides a promising
tool for preparing neural cells for replacement therapies and a versatile system for …
tool for preparing neural cells for replacement therapies and a versatile system for …
Adult generation of glutamatergic olfactory bulb interneurons
The adult mouse subependymal zone (SEZ) harbors neural stem cells that are thought to
exclusively generate GABAergic interneurons of the olfactory bulb. We examined the adult …
exclusively generate GABAergic interneurons of the olfactory bulb. We examined the adult …
Activin A directs striatal projection neuron differentiation of human pluripotent stem cells
The efficient generation of striatal neurons from human embryonic stem cells (hESCs) and
induced pluripotent stem cells (hiPSCs) is fundamental for realising their promise in disease …
induced pluripotent stem cells (hiPSCs) is fundamental for realising their promise in disease …
Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not
Neurons of the peripheral nervous system have long been known to require survival factors
to prevent their death during development. But why they selectively become dependent on …
to prevent their death during development. But why they selectively become dependent on …
Target genes of Topoisomerase IIβ regulate neuronal survival and are defined by their chromatin state
Topoisomerases are essential for DNA replication in dividing cells, but their genomic targets
and function in postmitotic cells remain poorly understood. Here we show that a switch in the …
and function in postmitotic cells remain poorly understood. Here we show that a switch in the …
A dlx2-and pax6-dependent transcriptional code for periglomerular neuron specification in the adult olfactory bulb
MS Brill, M Snapyan, H Wohlfrom… - Journal of …, 2008 - Soc Neuroscience
Distinct olfactory bulb (OB) interneurons are thought to become specified depending on from
which of the different subregions lining the lateral ventricle wall they originate, but the role of …
which of the different subregions lining the lateral ventricle wall they originate, but the role of …
Generation of subtype-specific neurons from postnatal astroglia of the mouse cerebral cortex
C Heinrich, S Gascón, G Masserdotti, A Lepier… - Nature protocols, 2011 - nature.com
Instructing glial cells to generate neurons may prove to be a strategy to replace neurons that
have degenerated. Here, we describe a robust protocol for the efficient in vitro conversion of …
have degenerated. Here, we describe a robust protocol for the efficient in vitro conversion of …
[HTML][HTML] Single-cell profiling shows murine forebrain neural stem cells reacquire a developmental state when activated for adult neurogenesis
The transitions from developing to adult quiescent and activated neural stem cells (NSCs)
are not well understood. Here, we use single-cell transcriptional profiling and lineage tracing …
are not well understood. Here, we use single-cell transcriptional profiling and lineage tracing …
Identification of in vivo DNA-binding mechanisms of Pax6 and reconstruction of Pax6-dependent gene regulatory networks during forebrain and lens development
The transcription factor Pax6 is comprised of the paired domain (PD) and homeodomain
(HD). In the developing forebrain, Pax6 is expressed in ventricular zone precursor cells and …
(HD). In the developing forebrain, Pax6 is expressed in ventricular zone precursor cells and …