Disuse osteoporosis describes a state of bone loss due to local skeletal unloading or
systemic immobilization. This review will discuss advances in the field that have shed light …

Zebrafish are teleosts (bony fish) that share with mammals a common ancestor belonging to
the phylum Osteichthyes, from which their endoskeletal systems have been inherited …

Animal models are essential tools for addressing fundamental scientific questions about
skeletal diseases and for the development of new therapeutic approaches. Traditionally …

Osteoporosis is metabolic bone disease caused by an altered balance between bone
anabolism and catabolism. This dysregulated balance is responsible for fragile bones that …

Simple Summary The zebrafish is one of the most commonly used animals in scientific
research, but there remains a lack of consensus over good practice for zebrafish housing …

Osteoclasts and osteoblasts play a major role in bone tissue homeostasis. The homeostasis
and integrity of bone tissue are maintained by ensuring a balance between osteoclastic and …

Danio rerio (zebrafish) is an elective model organism for the study of vertebrate
development because of its high degree of homology with human genes and organs …

Background Scales are mineralised exoskeletal structures that are part of the dermal
skeleton. Scales have been mostly lost during evolution of terrestrial vertebrates whilst bony …

The identification of disease-causing mutations has in recent years progressed immensely
due to whole genome sequencing approaches using patient material. The task accordingly …

Osteoporosis, characterized by bone mineral density reduction, bone mass loss, increased
bone fragility, and propensity to fractures, is a common disease in older individuals and one …