Pharmacological principles guiding prolonged glucocorticoid treatment in ARDS

GU Meduri, D Annane, M Confalonieri… - Intensive care …, 2020 - Springer
Current literature addressing the pharmacological principles guiding glucocorticoid (GC)
administration in ARDS is scant. This paucity of information may have led to the …

Prolonged glucocorticoid treatment is associated with improved ARDS outcomes: analysis of individual patients' data from four randomized trials and trial-level meta …

GU Meduri, L Bridges, MC Shih, PE Marik… - Intensive care …, 2016 - Springer
Purpose To investigate the effect of prolonged glucocorticoid treatment for patients with
acute respiratory distress syndrome (ARDS). Methods We conducted two sets of intention-to …

The REMAP-CAP (randomized embedded multifactorial adaptive platform for community-acquired pneumonia) study. Rationale and design

DC Angus, S Berry, RJ Lewis, F Al-Beidh… - Annals of the …, 2020 - atsjournals.org
There is broad interest in improved methods to generate robust evidence regarding best
practice, especially in settings where patient conditions are heterogenous and require …

Corticosteroids in acute lung injury: the dilemma continues

D Mokra, P Mikolka, P Kosutova, J Mokry - International journal of …, 2019 - mdpi.com
Acute lung injury (ALI) represents a serious heterogenous pulmonary disorder with high
mortality. Despite improved understanding of the pathophysiology, the efficacy of standard …

Hydrocortisone treatment in early sepsis-associated acute respiratory distress syndrome: results of a randomized controlled trial

S Tongyoo, C Permpikul, W Mongkolpun… - Critical Care, 2016 - Springer
Background Authors of recent meta-analyses have reported that prolonged glucocorticoid
treatment is associated with significant improvements in patients with severe pneumonia or …

Hydrocortisone infusion for severe community-acquired pneumonia: a preliminary randomized study

M Confalonieri, R Urbino, A Potena… - American journal of …, 2005 - atsjournals.org
We hypothesize that hydrocortisone infusion in severe community-acquired pneumonia
attenuates systemic inflammation and leads to earlier resolution of pneumonia and a …

Acute eosinophilic pneumonia. Causes, diagnosis, and management

F De Giacomi, R Vassallo, ES Yi… - American journal of …, 2018 - atsjournals.org
Acute eosinophilic pneumonia (AEP) is an uncommon acute respiratory illness of varying
severity that includes presentation as acute respiratory distress syndrome with fatal …

Peripheral muscle strength training in bed-bound patients with COPD receiving mechanical ventilation: effect of electrical stimulation

E Zanotti, G Felicetti, M Maini, C Fracchia - Chest, 2003 - Elsevier
Study objective To compare the effects of active limb mobilization (ALM) with or without
electrical stimulation (ES) on muscle strength, respiratory rate (RR), heart rate, oxygen …

Prolonged low-dose methylprednisolone treatment is highly effective in reducing duration of mechanical ventilation and mortality in patients with ARDS

GU Meduri, RAC Siemieniuk, RA Ness… - Journal of Intensive …, 2018 - Springer
An updated meta-analysis incorporating nine randomized trials (n= 816) investigating low-to-
moderate dose prolonged glucocorticoid treatment in acute respiratory distress syndrome …

Ventilation-induced chemokine and cytokine release is associated with activation of nuclear factor-κ B and is blocked by steroids

HD HELD, S BOETTCHER, L HAMANN… - American journal of …, 2001 - atsjournals.org
Recent clinical trials have shown that the survival of patients with acute respiratory distress
syndrome (ARDS) is improved by ventilation with reduced volumes. These studies …