Multipronged diagnostic and therapeutic strategies for Alzheimer's disease

M Ramesh, T Govindaraju - Chemical science, 2022 - pubs.rsc.org
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and a major
contributor to dementia cases worldwide. AD is clinically characterized by learning, memory …

An insight into the medicinal attributes of berberine derivatives: A review

S Gaba, A Saini, G Singh, V Monga - Bioorganic & medicinal chemistry, 2021 - Elsevier
In the last few decades, traditional natural products have been the center of attention for the
scientific community and exploration of their therapeutic abilities is proceeding perpetually …

A natural polyphenol activates and enhances GPX4 to mitigate amyloid-β induced ferroptosis in Alzheimer's disease

P Baruah, H Moorthy, M Ramesh, D Padhi… - Chemical …, 2023 - pubs.rsc.org
Ferroptosis, an iron-dependent cell death, plays a crucial role in the pathology of
Alzheimer's disease (AD). Several characteristics of AD, including excessive iron …

Lipid-coated MCM-41 mesoporous silica nanoparticles loaded with berberine improved inhibition of acetylcholine esterase and amyloid formation

AK Singh, SS Singh, AS Rathore… - ACS Biomaterials …, 2021 - ACS Publications
Selective permeability of the blood–brain barrier limits effective treatment of
neurodegenerative disorders. In the present study, brain-targeted lipid-coated mesoporous …

A Review of Fibraurea tinctoria and Its Component, Berberine, as an Antidiabetic and Antioxidant

I Purwaningsih, IP Maksum, D Sumiarsa, S Sriwidodo - Molecules, 2023 - mdpi.com
Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia caused
by resistance to insulin action, inadequate insulin secretion, or excessive glucagon …

Intracellular Sources of ROS/H2O2 in Health and Neurodegeneration: Spotlight on Endoplasmic Reticulum

T Konno, EP Melo, JE Chambers, E Avezov - Cells, 2021 - mdpi.com
Reactive oxygen species (ROS) are produced continuously throughout the cell as products
of various redox reactions. Yet these products function as important signal messengers …

Mechanistic insights for drug repurposing and the design of hybrid drugs for Alzheimer's disease

D Padhi, T Govindaraju - Journal of Medicinal Chemistry, 2022 - ACS Publications
The heterogeneity and complex nature of Alzheimer's disease (AD) is attributed to several
genetic risk factors and molecular culprits. The slow pace and increasing failure rate of …

Antioxidant silk fibroin composite hydrogel for rapid healing of diabetic wound

B Maity, S Alam, S Samanta… - Macromolecular …, 2022 - Wiley Online Library
Wound healing is a complex process requiring multiple biological pathways and chemical
responses to be activated and synchronized to recover tissue integrity. In normal …

Design-of-experiment-assisted fabrication of biodegradable polymeric nanoparticles: in vitro characterization, biological activity, and in vivo assessment

MA Mir, MH Akhter, O Afzal, SO Rab, ASA Altamimi… - ACS …, 2023 - ACS Publications
Berberine (BER) is an alkaloid obtained from berberis plant having broad biological
activities including anticancer. BER-encapsulated alginate (ALG)/chitosan (CHS) …

Research progress on the pharmacological effects of berberine targeting mitochondria

X Fang, H Wu, J Wei, R Miao, Y Zhang… - Frontiers in …, 2022 - frontiersin.org
Berberine is a natural active ingredient extracted from the rhizome of Rhizoma Coptidis,
which interacts with multiple intracellular targets and exhibits a wide range of …