Clefts of the lip and/or palate (CLP) are common birth defects of complex aetiology. CLP can
occur in isolation or as part of a broad range of chromosomal, Mendelian or teratogenic …

Orofacial clefts (OFCs) rank as the second most common congenital birth defect in the
United States after Down syndrome and are the most common head and neck congenital …

Orofacial clefts are common birth defects and can occur as isolated, nonsyndromic events or
as part of Mendelian syndromes. There is substantial phenotypic diversity in individuals with …

Clefts of the lip and palate are generally divided into two groups, isolated cleft palate and
cleft lip with or without cleft palate, representing a heterogeneous group of disorders …

The epithelial and mesenchymal cells involved in early embryonic facial development are
guided by complex regulatory mechanisms. Any factor perturbing the growth, approach and …

With an average worldwide prevalence of approximately 1.2/1000 live births, orofacial clefts
are the most common craniofacial birth defects in humans. Like other complex disorders …

Previously we have shown that nonsyndromic cleft lip with or without cleft palate (NSCL/P) is
strongly associated with SNPs in IRF6 (interferon regulatory factor 6). Here, we use …

Transcription factor paralogs may share a common role in staged or overlapping expression
in specific tissues, as in the Hox family. In other cases, family members have distinct roles in …

The Indian sub-continent remains one of the most populous areas of the world with an
estimated population of 1.1 billion in India alone. This yields an estimated 24.5 million births …

Heterozygous mutations in the transcription factor gene p63 are causative for several
syndromes, with ectodermal dysplasia, orofacial clefting and limb malformations as the key …