Advancements in chimeric antigen receptor engineered T-cell (CAR-T) therapy have
revolutionized treatment for several cancer types over the past decade. Despite this success …

Cell therapy offers the potential for curative treatment of cancers. Although T cells have been
the predominantly used cell type, natural killer (NK) cells have attracted great attention …

Chimeric antigen receptor (CAR) T cell therapy has been a great success in CD19+
hematological diseases. Natural killer (NK) CAR cells offer an alternative to CAR T cells with …

Despite the remarkable clinical efficacy of chimeric antigen receptor (CAR) T cells in
hematological malignancies, only a subset of patients achieves a durable complete …

Natural killer (NK) cells hold promise in cancer treatment due to their ability to
spontaneously lyse cancer cells. For clinical use, high quantities of pure, functional NK cells …

Owing to non-responsiveness of a high number of patients to the common melanoma
therapies, seeking novel approaches seem as an unmet requirement. Chimeric antigen …

Current treatments for T cell malignancies encounter issues of disease relapse and off-target
toxicity. Using T cell receptor (TCR) Vβ2 as a model, here we demonstrate the rapid …

Polymeric microspheres (PMs) have attracted great attention in the field of biomedicine in
the last several decades due to their small particle size, special functionalities shown on the …

Simple Summary The natural killer (NK) cells of the immune system identify and remove
stressed, infected, or cancerous cells in the body. This anti-tumor functionality has been …

Production of large amounts of functional NK and CAR-NK cells represents one of the
bottlenecks for NK-based immunotherapy. In this study, we developed a large-scale …