Microglia states and nomenclature: A field at its crossroads
Microglial research has advanced considerably in recent decades yet has been constrained
by a rolling series of dichotomies such as" resting versus activated" and" M1 versus M2." …
by a rolling series of dichotomies such as" resting versus activated" and" M1 versus M2." …
Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer's disease
Alzheimer's disease (AD) is characterized by synaptic loss, which can result from
dysfunctional microglial phagocytosis and complement activation. However, what signals …
dysfunctional microglial phagocytosis and complement activation. However, what signals …
Microglia: Immune and non-immune functions
K Borst, AA Dumas, M Prinz - Immunity, 2021 - cell.com
As resident macrophages of the central nervous system (CNS), microglia are associated
with diverse functions essential to the developing and adult brain during homeostasis and …
with diverse functions essential to the developing and adult brain during homeostasis and …
[HTML][HTML] Microglia modulate blood flow, neurovascular coupling, and hypoperfusion via purinergic actions
Disclosures: D. Máthé reported grants from European Union H2020 HCEMM-739593 and
from NRDIO, Hungary, TKP-BIOImaging-2020-4.1. 1-TKP2020 during the conduct of the …
from NRDIO, Hungary, TKP-BIOImaging-2020-4.1. 1-TKP2020 during the conduct of the …
Resident cardiac macrophages: Heterogeneity and function in health and disease
R Zaman, S Epelman - Immunity, 2022 - cell.com
Understanding tissue macrophage biology has become challenging in recent years due the
ever-increasing complexity in macrophage-subset identification and functional …
ever-increasing complexity in macrophage-subset identification and functional …
The neurovasculome: key roles in brain health and cognitive impairment: a scientific statement from the American Heart Association/American Stroke Association
Background: Preservation of brain health has emerged as a leading public health priority for
the aging world population. Advances in neurovascular biology have revealed an intricate …
the aging world population. Advances in neurovascular biology have revealed an intricate …
A Cre-deleter specific for embryo-derived brain macrophages reveals distinct features of microglia and border macrophages
Genetic tools to target microglia specifically and efficiently from the early stages of
embryonic development are lacking. We generated a constitutive Cre line controlled by the …
embryonic development are lacking. We generated a constitutive Cre line controlled by the …
Analyzing microglial phenotypes across neuropathologies: a practical guide
M Schwabenland, W Brück, J Priller, C Stadelmann… - Acta …, 2021 - Springer
As extremely sensitive immune cells, microglia act as versatile watchdogs of the central
nervous system (CNS) that tightly control tissue homeostasis. Therefore, microglial activation …
nervous system (CNS) that tightly control tissue homeostasis. Therefore, microglial activation …
A comparative analysis of microglial inducible Cre lines
TE Faust, PA Feinberg, C O'Connor, R Kawaguchi… - Cell reports, 2023 - cell.com
Cre/loxP technology has revolutionized genetic studies and allowed for spatial and temporal
control of gene expression in specific cell types. Microglial biology has particularly benefited …
control of gene expression in specific cell types. Microglial biology has particularly benefited …