Progress in the field of precision medicine has changed the landscape of cancer therapy.
Precision medicine is propelled by technologies that enable molecular profiling, genomic …

Gene therapy has long held promise to correct a variety of human diseases and defects.
Discovery of the Clustered Regularly-Interspaced Short Palindromic Repeats (CRISPR), the …

TALEN were the first easy-to-use genome editing technology and sparked the genome
editing revolution. Their application in multiple species brought targeted mutagenesis to the …

The genetic improvement of fish for aquaculture and related fisheries has seen huge
advances over recent years. Building upon the previous two editions of Aquaculture and …

Adeno-associated virus (AAV) has shown promising therapeutic efficacy with a good safety
profile in a wide range of animal models and human clinical trials. With the advent of …

Gene editing (GE) has become one of the mainstream bioengineering technologies over the
past two decades, mainly fueled by the rapid development of the CRISPR/Cas system since …

Tyrosine-type site-specific recombinases (T-SSRs) have opened new avenues for the
predictable modification of genomes as they enable precise genome editing in heterologous …

Genome editing (GE) entails the modification of specific genomic sequences in living cells
for the purpose of determining, changing, or expanding their function (s). Typically, GE …

Targeted nucleases, including zinc-finger nucleases (ZFNs), transcription activator-like
(TAL) effector nucleases (TALENs) and clustered regularly interspaced short palindromic …

Gene therapy by engineered nucleases is a genetic intervention being investigated for
curing the hereditary disorders by targeting selected genes with specific nucleotides for …