The Hippo signaling pathway inhibits the activity of the oncogenic YAP (Yes-associated
protein)/TAZ (transcriptional co-activator with PDZ-binding motif)–TEAD (TEA/ATTS domain) …

The Hippo pathway and its downstream effectors, the YAP and TAZ transcriptional
coactivators, are deregulated in multiple different types of human cancer and are required …

TEAD transcription factors are responsible for the transcriptional output of Hippo signaling.
TEAD activity is primarily regulated by phosphorylation of its coactivators, YAP and TAZ. In …

The yes‐associated protein (YAP) regulates the transcriptional activity of the TEAD
transcription factors that are key in the control of organ morphogenesis. YAP interacts with …

The Hippo signaling pathway is a highly conserved signaling network that plays a central
role in regulating cellular growth, proliferation, and organ size. This pathway consists of a …

Due to the ongoing global warming, the risk of heatwaves in the oceans is continuously
increasing while our understanding of the physiological response of Litopenaeus vannamei …

The hippo signaling pathway is a central tumor suppressor cascade frequently inactivated in
selected human cancers, leading to the aberrant activation of TEAD transcription factors …

Precise genome engineering is essential for both basic and applied research, permitting the
manipulation of genes and gene products in predictable ways. The irruption of the …

TEAD3 acts as a transcription factor in many tumors to promote tumor occurrence and
development. But in prostate cancer (PCa), it appears as a tumor suppressor gene. Recent …

Human embryonic stem cells (hESCs) are naturally equipped to maintain genome integrity
to minimize genetic mutations during early embryo development. However, genetic …