Natural products and synthetic small molecules can be used to perturb, dissect and
manipulate biological processes, thereby providing the basis for drug development. Over the …

Cancer stem cells (CSCs) represent a subset of cells within tumours that exhibit self-renewal
properties and the capacity to seed tumours. CSCs are typically refractory to conventional …

Abstract Background Non-coding RNAs are now recognized as fundamental components of
the cellular processes. Non-coding RNAs are composed of different classes, including …

The re-emergence of Zika virus (ZIKV) in the Western Hemisphere has resulted in global
public health crisis since 2015. ZIKV preferentially infects and targets human neural …

Type I interferons (IFNs) induce hundreds of IFN-stimulated genes (ISGs) in response to viral
infection. Induction of these ISGs must be regulated for an efficient and controlled antiviral …

Base on improving the solubility and permeability of enoxacin (EX) to enhance the
antibacterial activity in vitro, three new pharmaceutical salts/cocrystals of EX with oxalic acid …

MicroRNAs (miRNAs) have been implicated in oxidative metabolism and brown/beige
adipocyte identity. Here, we tested whether widespread changes in miRNA expression …

Abstract Enoxacin (ENX), a third-generation fluoroquinolone, demonstrates broad-spectrum
antibacterial activities and is widely applied for the treatment of various bacterial infections …

Simple Summary Enoxacin is a second-generation quinolone with promising anticancer
activity. In contrast to other members of the quinolone group, it exhibits an extraordinary …

MicroRNAs are key factors in the regulation of gene expression and their deregulation has
been directly linked to various pathologies such as cancer. The use of small molecules to …