AI-based protein structure prediction in drug discovery: impacts and challenges
M Schauperl, RA Denny - Journal of Chemical Information and …, 2022 - ACS Publications
Proteins are the molecular machinery of the human body, and their malfunctioning is often
responsible for diseases, making them crucial targets for drug discovery. The three …
responsible for diseases, making them crucial targets for drug discovery. The three …
AKT inhibitors: new weapons in the fight against breast cancer?
F Martorana, G Motta, G Pavone, L Motta… - Frontiers in …, 2021 - frontiersin.org
The serine/threonine kinase AKT is a key component of the PI3K/AKT/mTOR signaling
pathway as it exerts a pivotal role in cell growth, proliferation, survival, and metabolism …
pathway as it exerts a pivotal role in cell growth, proliferation, survival, and metabolism …
Prospects of targeting PI3K/AKT/mTOR pathway in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) has one of the worst prognoses among all
malignancies. PI3K/AKT/mTOR signaling pathway, a main downstream effector of KRAS is …
malignancies. PI3K/AKT/mTOR signaling pathway, a main downstream effector of KRAS is …
Potential of curcumin in skin disorders
Curcumin is a compound isolated from turmeric, a plant known for its medicinal use.
Recently, there is a growing interest in the medical community in identifying novel, low-cost …
Recently, there is a growing interest in the medical community in identifying novel, low-cost …
Targeting PI3K/AKT/mTOR signaling pathway in breast cancer
Simple Summary PI3K signaling pathway plays an essential role in many cellular processes
and is frequently altered in breast cancer, leading to increased tumor growth and reduced …
and is frequently altered in breast cancer, leading to increased tumor growth and reduced …
New promise and opportunities for allosteric kinase inhibitors
Drugs that function through allosteric inhibition of kinase signaling represent a promising
approach for the targeted discovery of therapeutics. The majority of developed allosteric …
approach for the targeted discovery of therapeutics. The majority of developed allosteric …
An overview of kinase downregulators and recent advances in discovery approaches
B Wang, H Wu, C Hu, H Wang, J Liu… - Signal Transduction and …, 2021 - nature.com
Since the clinical approval of imatinib, the discovery of protein kinase downregulators
entered a prosperous age. However, challenges still exist in the discovery of kinase …
entered a prosperous age. However, challenges still exist in the discovery of kinase …
[HTML][HTML] Overcoming adaptive resistance to KRAS and MEK inhibitors by co-targeting mTORC1/2 complexes in pancreatic cancer
Activating KRAS mutations are found in over 90% of pancreatic ductal adenocarcinomas
(PDACs), yet KRAS has remained a difficult target to inhibit pharmacologically. Here, we …
(PDACs), yet KRAS has remained a difficult target to inhibit pharmacologically. Here, we …
Rational design of allosteric modulators: Challenges and successes
A Chatzigoulas, Z Cournia - Wiley Interdisciplinary Reviews …, 2021 - Wiley Online Library
Recent advances in structural biology and computational techniques have revealed
allosteric mechanisms for an abundance of targets leading to the establishment of rational …
allosteric mechanisms for an abundance of targets leading to the establishment of rational …
Activation of the essential kinase PDK1 by phosphoinositide-driven trans-autophosphorylation
phosphoinositide-dependent kinase 1 (PDK1) is an essential serine/threonine protein
kinase, which plays a crucial role in cell growth and proliferation. It is often referred to as a …
kinase, which plays a crucial role in cell growth and proliferation. It is often referred to as a …