Research progress of glutathione peroxidase family (GPX) in redoxidation

J Pei, X Pan, G Wei, Y Hua - Frontiers in pharmacology, 2023 - frontiersin.org
Maintaining the balance of a cell's redox function is key to determining cell fate. In the critical
redox system of mammalian cells, glutathione peroxidase (GPX) is the most prominent …

Selenium: an antioxidant with a critical role in anti-aging

G Bjørklund, M Shanaida, R Lysiuk, H Antonyak… - Molecules, 2022 - mdpi.com
Aging is characterized by an imbalance between damage inflicted by reactive oxygen
species (ROS) and the antioxidative defenses of the organism. As a significant nutritional …

Recent advances in the synthesis and antioxidant activity of low molecular mass organoselenium molecules

JM Anghinoni, PT Birmann, MJ da Rocha, CS Gomes… - Molecules, 2023 - mdpi.com
Selenium is an essential trace element in living organisms, and is present in selenoenzymes
with antioxidant activity, like glutathione peroxidase (GPx) and thioredoxin reductase (TrxR) …

Cheminformatics-based discovery of new organoselenium compounds with potential for the treatment of cutaneous and visceral leishmaniasis

FA Ugbe, GA Shallangwa, A Uzairu… - Journal of …, 2024 - Taylor & Francis
Leishmaniasis affects more than 12 million humans globally and a further 1 billion people
are at risk in leishmaniasis endemic areas. The lack of a vaccine for leishmaniasis coupled …

Nature and energetics of low-lying excited singlets/triplets and intersystem crossing rates in selone analogs of perylenediimide: A theoretical perspective

AM Tedy, AK Manna - The Journal of Chemical Physics, 2024 - pubs.aip.org
The structural rigidity and chemical diversity of the highly fluorescent perylenediimide (PDI)
provide wide opportunities for developing triplet photosensitizers with sufficiently increased …

Synthesis, DNA-binding, molecular docking, and cytotoxic activity of a new 4-amino-N-(5-selenocyanatothiazol-2-yl) benzenesulfonamide

ZO Owidah, RM Alansari, MA Gouda… - Journal of Molecular …, 2023 - Elsevier
Abstract Triselenium dicyanide (TSD, 2) was combined with 4-amino-N-(thiazol-2-yl)
benzenesulfonamide (3) in DMSO to form 4-amino-N-(5-selenocyanatothiazol-2-yl) …

Evaluation of the photoprotective and antioxidant potential of an avobenzone derivative

AJ Pasuch Gluzezak, JL Dos Santos… - Frontiers in …, 2024 - frontiersin.org
Solar radiation can cause damage to the skin, and the use of sunscreens is one of the main
protective measures. However, photounstable ultraviolet (UV) filters can generate …

Glutathione Peroxidase-like Antioxidant Activity of 1,3-Benzoselenazoles: Synthesis and In Silico Molecular Docking Studies as Pancreatic Lipase Inhibitors

M Yadav, VP Singh - The Journal of Organic Chemistry, 2023 - ACS Publications
The synthesis of 1, 3-benzoselenazoles was achieved by the reaction of corresponding bis
[3-amino-N-(p-tolyl) benzamide-2-yl] diselenide, bis [3-amino-N-(4-methoxyphenyl) …

Computational evaluation of the inhibitory potential of some urea, thiourea, and selenourea derivatives of diselenides against leishmaniasis: 2D-QSAR …

FA Ugbe, EI Edache, SE Adeniji, DE Arthur… - Journal of Molecular …, 2024 - Elsevier
Leishmaniasis affects more than twelve million people globally and a further one billion
people are at risk in leishmaniasis endemic areas. The lack of a vaccine for leishmaniasis …

Transannular Selenocyclofunctionalization of 1, 5-cyclooctadiene: The Antioxidant Properties of 9-selenabicyclo [3.3. 1] nonane Derivatives and the Discovery of …

MV Musalov, IS Kapustina, EV Spiridonova… - Inorganics, 2023 - mdpi.com
Oxidative stress is the cause of various pathologies and disorders of cellular functions.
Substances that reduce the pathological effect of oxidative stress on homeostasis include …