The microbiome as a key regulator of female genital tract barrier function
A Plesniarski, AB Siddik, RC Su - Frontiers in cellular and infection …, 2021 - frontiersin.org
The microbiome, the collection of microbial species at a site or compartment, has been an
underappreciated realm of human health up until the last decade. Mounting evidence …
underappreciated realm of human health up until the last decade. Mounting evidence …
In vitro modelling of the physiological and diseased female reproductive system
A Stejskalova, H Vankelecom, M Sourouni, MY Ho… - Acta biomaterialia, 2021 - Elsevier
The maladies affecting the female reproductive tract (FRT) range from infections to
endometriosis to carcinomas. In vitro models of the FRT play an increasingly important role …
endometriosis to carcinomas. In vitro models of the FRT play an increasingly important role …
Vaginal microbiome-hormonal contraceptive interactions associate with the mucosal proteome and HIV acquisition
L Noël-Romas, M Perner, R Molatlhegi… - PLoS …, 2020 - journals.plos.org
Alterations to the mucosal environment of the female genital tract, such as genital
inflammation, have been associated with increased HIV acquisition in women. As the …
inflammation, have been associated with increased HIV acquisition in women. As the …
A phase I study to assess safety, pharmacokinetics, and pharmacodynamics of a vaginal insert containing tenofovir alafenamide and elvitegravir
AR Thurman, LA Ouattara, N Yousefieh… - Frontiers in Cellular …, 2023 - frontiersin.org
Background New multi-purpose prevention technology (MPT) products are needed to
prevent human immunodeficiency virus (HIV) and herpes simplex virus type 2 (HSV2). In this …
prevent human immunodeficiency virus (HIV) and herpes simplex virus type 2 (HSV2). In this …
Regular use of depot medroxyprogesterone acetate causes thinning of the superficial lining and apical distribution of human immunodeficiency virus target cells in the …
Background The hormonal contraceptive depot medroxyprogesterone acetate (DMPA) may
be associated with an increased risk of acquiring human immunodeficiency virus (HIV). We …
be associated with an increased risk of acquiring human immunodeficiency virus (HIV). We …
Differential off-target glucocorticoid activity of progestins used in endocrine therapy
M Komane, C Avenant, R Louw-du Toit, DJ Africander… - Steroids, 2022 - Elsevier
The glucocorticoid receptor (GR) regulates transcription of genes involved in multiple
processes. Medroxyprogesterone acetate (MPA), widely used in the injectable contraceptive …
processes. Medroxyprogesterone acetate (MPA), widely used in the injectable contraceptive …
Contraceptive effects on the cervicovaginal microbiome: Recent evidence including randomized trials
Background Until recently, most data regarding the effects of non‐barrier contraceptives on
the mucosal microbiome have derived from observational studies, which are potentially …
the mucosal microbiome have derived from observational studies, which are potentially …
Multi-omics analysis of the cervical epithelial integrity of women using depot medroxyprogesterone acetate
F Bradley, M Franzén Boger, V Kaldhusdal… - PLoS …, 2022 - journals.plos.org
Depot medroxyprogesterone acetate (DMPA) is an injectable hormonal contraceptive used
by millions of women worldwide. However, experimental studies have associated DMPA use …
by millions of women worldwide. However, experimental studies have associated DMPA use …
Is the injectable contraceptive Depo-medroxyprogesterone acetate (DMPA-IM) associated with an increased risk for HIV acquisition? The jury is still out
JP Hapgood - AIDS research and human retroviruses, 2020 - liebertpub.com
Intramuscular depo-medroxyprogesterone acetate (DMPA-IM) is the most widely used
hormonal contraceptive in sub-Saharan Africa. Previous meta-analyses of observational …
hormonal contraceptive in sub-Saharan Africa. Previous meta-analyses of observational …
Antigen presenting cells link the female genital tract microbiome to mucosal inflammation, with hormonal contraception as an additional modulator of inflammatory …
EH Byrne, M Farcasanu, SM Bloom, N Xulu… - Frontiers in cellular …, 2021 - frontiersin.org
The microbiome of the female genital tract (FGT) is closely linked to reproductive health
outcomes. Diverse, anaerobe-dominated communities with low Lactobacillus abundance …
outcomes. Diverse, anaerobe-dominated communities with low Lactobacillus abundance …