Molecular basis of bacterial host interactions by Gram-positive targeting bacteriophages

M Dunne, M Hupfeld, J Klumpp, MJ Loessner - Viruses, 2018 - mdpi.com
The inherent ability of bacteriophages (phages) to infect specific bacterial hosts makes them
ideal candidates to develop into antimicrobial agents for pathogen-specific remediation in …

Phage adsorption to gram-positive bacteria

A Leprince, J Mahillon - Viruses, 2023 - mdpi.com
The phage life cycle is a multi-stage process initiated by the recognition and attachment of
the virus to its bacterial host. This adsorption step depends on the specific interaction …

Predicting bacteriophage hosts based on sequences of annotated receptor-binding proteins

D Boeckaerts, M Stock, B Criel, H Gerstmans… - Scientific reports, 2021 - nature.com
Nowadays, bacteriophages are increasingly considered as an alternative treatment for a
variety of bacterial infections in cases where classical antibiotics have become ineffective …

In vitro characteristics of phages to guide 'real life'phage therapy suitability

E Casey, D Van Sinderen, J Mahony - Viruses, 2018 - mdpi.com
The increasing problem of antibiotic-resistant pathogens has put enormous pressure on
healthcare providers to reduce the application of antibiotics and to identify alternative …

[PDF][PDF] Cell wall homeostasis in lactic acid bacteria: threats and defences

B Martínez, A Rodríguez, S Kulakauskas… - FEMS microbiology …, 2020 - academic.oup.com
Lactic acid bacteria (LAB) encompasses industrially relevant bacteria involved in food
fermentations as well as health-promoting members of our autochthonous microbiota. In the …

Structure of the host cell recognition and penetration machinery of a Staphylococcus aureus bacteriophage

JL Kizziah, KA Manning, AD Dearborn… - PLoS …, 2020 - journals.plos.org
Staphylococcus aureus is a common cause of infections in humans. The emergence of
virulent, antibiotic-resistant strains of S. aureus is a significant public health concern. Most …

Adsorption of bacteriophages on bacterial cells

AV Letarov, EE Kulikov - Biochemistry (Moscow), 2017 - Springer
The biological functions of bacteriophage virions come down to the solution of three basic
problems: to provide protection of viral nucleic acid from the factors of extracellular …

Conserved and Diverse Traits of Adhesion Devices from Siphoviridae Recognizing Proteinaceous or Saccharidic Receptors

A Goulet, S Spinelli, J Mahony, C Cambillau - Viruses, 2020 - mdpi.com
Bacteriophages can play beneficial roles in phage therapy and destruction of food
pathogens. Conversely, they play negative roles as they infect bacteria involved in …

Structure, function and assembly of the long, flexible tail of siphophages

R Linares, CA Arnaud, S Degroux, G Schoehn… - Current Opinion in …, 2020 - Elsevier
Highlights•Siphophage tails share a common core architecture despite great sequence
diversity.•Myophage tails and phage-related injection systems also share the same …

[HTML][HTML] Present impact of AlphaFold2 revolution on structural biology, and an illustration with the structure prediction of the bacteriophage J-1 host adhesion device

A Goulet, C Cambillau - Frontiers in Molecular Biosciences, 2022 - frontiersin.org
In 2021, the release of AlphaFold2-the DeepMind's machine-learning protein structure
prediction program-revolutionized structural biology. Results of the CASP14 contest were an …