Increased expression of complement C1r, C1s and C3 in kidney cells plays an important
role in the pathogenesis of kidney fibrosis. Our studies suggest that activation of complement …

Complement analysis in the clinic is usually associated with the quantification of C3 and C4,
measurement of C1-inhibitor and screening for complement activity. These analyses have …

Understanding molecular mechanisms that dictate B cell diversity is important for targeting B
cells as anti-cancer treatment. Through the single-cell dissection of B cell heterogeneity in …

Toll-like receptors (TLRs) and complement are 2 components of innate immunity that are
critical for first-line host defense and elicitation of adaptive immune responses. Many …

Variants of the CFH gene, encoding complement factor H (CFH), show strong association
with age-related macular degeneration (AMD), a major cause of blindness. Here, we used …

Age-related macular degeneration (AMD) is a leading cause of visual dysfunction
worldwide. Amyloid β (Aβ) peptides, Aβ1–40 (Aβ40) and Aβ1–42 (Aβ42), have been …

Beyond its role in immunity, complement mediates a wide range of functions in the context of
morphogenetic or tissue remodeling processes. Angiogenesis is crucial during tissue …

Microglial priming predisposes the brain to neurodegeneration and affects disease
progression. The signal to switch from the quiescent to the primed state is unknown. We …

Background & Aims: The complement pathway is an important component of the innate and
adaptive immune response. Here we tested the hypothesis that activation of complement is …

BACKGROUND & AIMS: Complement is involved in the development of alcoholic liver
disease in mice; however, the mechanisms for complement activation during ethanol …