Advances in hydrogel technology have unlocked unique and valuable capabilities that are
being applied to a diverse set of translational applications. Hydrogels perform functions …

Allergic diseases such as allergic rhinitis (AR), allergic asthma (AAS), atopic dermatitis (AD),
food allergy (FA), and eczema are systemic diseases caused by an impaired immune …

Faced with the challenges posed by infectious diseases and cancer, nucleic acid vaccines
present excellent prospects in clinical applications. Compared with traditional vaccines …

Checkpoint blockade immunotherapy (CBI) awakes a host innate immune system and
reactivates cytotoxic T cells to elicit durable response in some cancer patients. Now, a …

Synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs trigger cells
that express Toll-like receptor 9 (including human plasmacytoid dendritic cells and B cells) …

Designed oligonucleotides can self-assemble into DNA nanostructures with well-defined
structures and uniform sizes, which provide unprecedented opportunities for biosensing …

DNA from bacteria has stimulatory effects on mammalian immune cells,,, which depend on
the presence of unmethylated CpG dinucleotides in the bacterial DNA. In contrast …

Dendritic cells (DCs) are antigen-presenting cells with a unique ability to induce primary
immune responses. DCs capture and transfer information from the outside world to the cells …

Organisms throughout biology need to maintain the integrity of their genome. From bacteria
to vertebrates, life has established sophisticated mechanisms to detect and eliminate foreign …

Dendritic cells take up antigens in peripheral tissues, process them into proteolytic peptides,
and load these peptides onto major histocompatibility complex (MHC) class I and II …