Mechanisms regulating PD-L1 expression in cancers and associated opportunities for novel small-molecule therapeutics
Antagonistic antibodies targeting the inhibitory immune-checkpoint receptor PD-1 or its
ligand PD-L1 are used to treat a wide range of cancer types and can substantially improve …
ligand PD-L1 are used to treat a wide range of cancer types and can substantially improve …
Regulatory mechanisms of immune checkpoints PD-L1 and CTLA-4 in cancer
The cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4)/B7 and programmed death 1
(PD-1)/programmed cell death-ligand 1 (PD-L1) are two most representative immune …
(PD-1)/programmed cell death-ligand 1 (PD-L1) are two most representative immune …
Regulation of PD-L1 expression in the tumor microenvironment
M Yi, M Niu, L Xu, S Luo, K Wu - Journal of hematology & oncology, 2021 - Springer
Abstract Programmed death-ligand 1 (PD-L1) on cancer cells engages with programmed
cell death-1 (PD-1) on immune cells, contributing to cancer immune escape. For multiple …
cell death-1 (PD-1) on immune cells, contributing to cancer immune escape. For multiple …
Emerging phagocytosis checkpoints in cancer immunotherapy
Cancer immunotherapy, mainly including immune checkpoints-targeted therapy and the
adoptive transfer of engineered immune cells, has revolutionized the oncology landscape as …
adoptive transfer of engineered immune cells, has revolutionized the oncology landscape as …
Research progress of therapeutic effects and drug resistance of immunotherapy based on PD-1/PD-L1 blockade
K Pang, ZD Shi, LY Wei, Y Dong, YY Ma, W Wang… - Drug Resistance …, 2023 - Elsevier
The binding of programmed death-1 (PD-1) on the surface of T cells and PD-1 ligand 1 (PD-
L1) on tumor cells can prevent the immune-killing effect of T cells on tumor cells and …
L1) on tumor cells can prevent the immune-killing effect of T cells on tumor cells and …
Intratumoral copper modulates PD-L1 expression and influences tumor immune evasion
Therapeutic checkpoint antibodies blocking programmed death receptor 1/programmed
death ligand 1 (PD-L1) signaling have radically improved clinical outcomes in cancer …
death ligand 1 (PD-L1) signaling have radically improved clinical outcomes in cancer …
Regulation and function of the PD-L1 checkpoint
Expression of programmed death-ligand 1 (PD-L1) is frequently observed in human
cancers. Binding of PD-L1 to its receptor PD-1 on activated T cells inhibits anti-tumor …
cancers. Binding of PD-L1 to its receptor PD-1 on activated T cells inhibits anti-tumor …
Roles of PD-1/PD-L1 pathway: signaling, cancer, and beyond
L Ai, A Xu, J Xu - Regulation of Cancer Immune Checkpoints: Molecular …, 2020 - Springer
Immunotherapies that target PD-1/PD-L1 axis have shown unprecedented success in a wide
variety of human cancers. PD-1 is one of the key coinhibitory receptors expressed on T cells …
variety of human cancers. PD-1 is one of the key coinhibitory receptors expressed on T cells …
[HTML][HTML] Mechanisms controlling PD-L1 expression in cancer
The engagement of programmed cell death protein 1 (PD-1; encoded by the PDCD1 gene)
receptor expressed on activated T cells and its ligand, programmed death-ligand 1 (PD-L1; …
receptor expressed on activated T cells and its ligand, programmed death-ligand 1 (PD-L1; …
[HTML][HTML] Tumour necrosis factor signalling in health and disease
J Holbrook, S Lara-Reyna, H Jarosz-Griffiths… - …, 2019 - ncbi.nlm.nih.gov
The master pro-inflammatory cytokine, tumour necrosis factor (TNF), has been shown to
modulate multiple signalling pathways, with wide-ranging downstream effects. TNF plays a …
modulate multiple signalling pathways, with wide-ranging downstream effects. TNF plays a …