Actinomycetes are a diverse family of filamentous bacteria that produce a plethora of natural
products relevant for agriculture, biotechnology and medicine, including the majority of the …

Dangerous, antibiotic resistant bacteria have been observed with increasing frequency over
the past several decades. In this review the factors that have been linked to this …

The spread of resistant bacteria, leading to untreatable infections, is a major public health
threat but the pace of antibiotic discovery to combat these pathogens has slowed down …

Streptomycetes are the most abundant source of antibiotics. Typically, each species
produces several antibiotics, with the profile being species specific. Streptomyces coelicolor …

Actinobacteria are Gram-positive bacteria with high G+ C DNA content that constitute one of
the largest bacterial phyla, and they are ubiquitously distributed in both aquatic and …

Covering: 2000 to 2018 The antimicrobial activity of many of their natural products has
brought prominence to the Streptomycetaceae, a family of Gram-positive bacteria that …

Intercellular signaling is indispensable for single cells to form complex biological structures,
such as biofilms, tissues and organs. The genetic tools available for engineering …

We have developed a general profile for the proteins of the TetR family of repressors. The
stretch that best defines the profile of this family is made up of 47 amino acid residues that …

While the biological functions of most of the secondary metabolites made by streptomycetes
are not known, it is inconceivable that they do not play an adaptive ecological role. The …

To construct a versatile model host for heterologous expression of genes encoding
secondary metabolite biosynthesis, the genome of the industrial microorganism …