The~ 100 MB genome of C. elegans codes for~ 20,000 protein-coding genes many of which
are required for the function of the nervous system, composed of 302 neurons in the adult …

The accumulation of protein aggregates is the hallmark of many neurodegenerative
diseases. The dysregulation of protein homeostasis (or proteostasis) caused by acute …

Programmed cell death is an integral component of Caenorhabditis elegans development.
Genetic and reverse genetic studies in C. elegans have led to the identification of many …

The studies of cell fate and lineage specification are fundamental to our understanding of
the development of multicellular organisms. Caenorhabditis elegans has been one of the …

In the nematode Caenorhabditis elegans, neurons are generated from asymmetric divisions
in which a mother cell divides to produce daughters that differ in fate. Here, we demonstrate …

Programmed cell death occurs in a highly reproducible manner during Caenorhabditis
elegans development. We demonstrate that, during embryogenesis, miR-35 and miR-58 …

Asymmetric cell division and apoptosis (programmed cell death) are two fundamental
processes that are important for the development and function of multicellular organisms …

Neuroblasts generate neurons with different functions by asymmetric cell division, cell cycle
exit and differentiation. The underlying transcriptional regulatory pathways remain elusive …

Asymmetric cell divisions produce daughter cells with distinct sizes and fates, a process
important for generating cell diversity during development. Many Caenorhabditis elegans …

Asymmetric cell divisions often generate daughter cells of unequal size in addition to
different fates. In some contexts, daughter cell size asymmetry is thought to be a key input to …