Simple Summary The tumor immune escape mechanisms are key factors in cancer
progression and metastasis. They are an undeniable hurdle for successful cancer treatment …

In recent decades, immune checkpoint blockade and chimeric antigen receptor T cell (CAR-
T) therapy are two milestone achievements in clinical immunotherapy. However, both show …

In addition to the contribution of cancer cells, the solid tumor microenvironment (TME) has a
critical role in determining tumor expansion, antitumor immunity, and the response to …

Tumor microenvironment (TME), which is characterized by hypoxia, widely exists in solid
tumors. As a current research hotspot in the TME, hypoxia is expected to become a key …

The field of immuno-oncology has revolutionized cancer patient care and improved survival
and quality of life for patients. Much of the focus in the field has been on exploiting the power …

Immune checkpoint molecules play a pivotal role in the initiation, regulation, and termination
of immune responses. Tumor cells exploit these checkpoints to dampen immune cell …

The immunosuppressive tumor microenvironment (TME) remains one of the most prevailing
barriers obstructing the implementation of effective immunotherapy against solid-state …

Few cancers can be targeted efficiently by engineered T cell strategies. Here, we show that
γδ T cell antigen receptor (γδ TCR)-mediated cancer metabolome targeting can be …

Major histocompatibility complex class I related chain A (MICA) is an important and stress-
induced ligand of the natural killer group 2 member D receptor (NKG2D) that is expressed in …

Background The advent of chimeric antigen receptor (CAR) T cell therapies has transformed
the treatment of hematological malignancies; however, broader therapeutic success of CAR …