Significance of angiotensin 1–7 coupling with MAS1 receptor and other GPCRs to the renin‐angiotensin system: IUPHAR Review 22
SS Karnik, KD Singh, K Tirupula… - British journal of …, 2017 - Wiley Online Library
Angiotensins are a group of hormonal peptides and include angiotensin II and angiotensin 1–
7 produced by the renin angiotensin system. The biology, pharmacology and biochemistry of …
7 produced by the renin angiotensin system. The biology, pharmacology and biochemistry of …
Itch: from the skin to the brain–peripheral and central neural sensitization in chronic itch
Similar to chronic pain, chronic itch is frequently linked to neural sensitization, a
phenomenon wherein the nervous system becomes hypersensitive to stimuli. This process …
phenomenon wherein the nervous system becomes hypersensitive to stimuli. This process …
Peripheral nitric oxide signaling directly blocks inflammatory pain
Pain is a classical sign of inflammation, and sensitization of primary sensory neurons (PSN)
is the most important mediating mechanism. This mechanism involves direct action of …
is the most important mediating mechanism. This mechanism involves direct action of …
[HTML][HTML] Similarities and differences in peripheral itch and pain pathways in atopic dermatitis
Atopic dermatitis (AD) is predominantly characterized by intense itching, but concomitant
skin pain is experienced by more than 40% of patients. Patients with AD display …
skin pain is experienced by more than 40% of patients. Patients with AD display …
Cellular and molecular mechanisms driving neuropathic pain: recent advancements and challenges
Introduction: Current pharmacotherapeutics for neuropathic pain offer only symptomatic
relief without treating the underlying pathophysiology. Additionally, they are associated with …
relief without treating the underlying pathophysiology. Additionally, they are associated with …
Combination chemotherapy in rodents: A model for chemotherapy-induced neuropathic pain and pharmacological screening
Chemotherapy-induced neuropathic pain (CINP) remains a therapeutic challenge, with no
US-FDA approved drugs or effective treatments available. Despite significant progress in …
US-FDA approved drugs or effective treatments available. Despite significant progress in …
Mas-related G protein-coupled receptor D participates in inflammatory pain by promoting NF-κB activation through interaction with TAK1 and IKK complex
L Lan, M Xu, J Li, L Liu, M Xu, C Zhou, L Shen, Z Tang… - Cellular …, 2020 - Elsevier
Mas-related G protein-coupled receptor D (MrgprD) is mainly expressed in small-diameter
sensory neurons of the dorsal root ganglion (DRG). Results from previous studies suggest …
sensory neurons of the dorsal root ganglion (DRG). Results from previous studies suggest …
[HTML][HTML] The cellular basis of protease-activated receptor 2–evoked mechanical and affective pain
Abstract Protease-activated receptor 2 (PAR2) has long been implicated in inflammatory and
visceral pain, but the cellular basis of PAR2-evoked pain has not been delineated. Although …
visceral pain, but the cellular basis of PAR2-evoked pain has not been delineated. Although …
The signaling pathway and polymorphisms of Mrgprs
Mas-related G protein-coupled receptors (Mrgprs) are a family of receptors implicated in a
diverse array of human diseases. Since their discovery in 2001, great progress has been …
diverse array of human diseases. Since their discovery in 2001, great progress has been …
Mas‐related G protein‐coupled receptor C11 (Mrgprc11) induces visceral hypersensitivity in the mouse colon: A novel target in gut nociception?
S Van Remoortel, H Ceuleers, R Arora… - …, 2019 - Wiley Online Library
Background Visceral hypersensitivity, an important cause of abdominal pain in disorders
such as IBD and IBS, presents with a poorly understood pathophysiology and limited …
such as IBD and IBS, presents with a poorly understood pathophysiology and limited …