Ki-67 assessment is a key step in the diagnosis of neuroendocrine neoplasms (NENs) from
all anatomic locations. Several challenges exist related to quantifying the Ki-67 proliferation …

Lung neuroendocrine neoplasms (NENs) are a heterogeneous group of pulmonary
neoplasms showing different morphological patterns and clinical and biological …

The Ki‐67 proliferation index (PI) is a prognostic factor in neuroendocrine tumors (NETs)
and defines tumor grade. Analysis of Ki‐67 PI requires calculation of Ki‐67‐positive and Ki …

Cancer comprises epithelial tumor cells and associated stroma, often times referred to as the
“tumoral microenvironment”. Cancer-associated fibroblasts (CAFs) are the most notable …

Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are rare epithelial
neoplasms. Grading is based on mitotic activity or the percentage of Ki67-positive cells in a …

Quantification of Ki67 and mitosis is time consuming and subject to inter-observer
variabilities. Limited studies explored the impact of those variables on the results and the …

Background The Ki‐67 index is important for grading neuroendocrine tumors (NETs) in
cytology. However, different counting methods exist. Recently, augmented reality …

Thresholds and perceived significance of nuclear features of papillary thyroid carcinoma
(PTC) are continuing to evolve with our improved understanding of the clinical and …

Neuroendocrine neoplasms (NENs) span virtually all organ systems and exhibit a broad
spectrum of behavior, from indolent to highly aggressive. Historically, nomenclature and …

Background Neuroendocrine tumors (NETs) represent a diverse group of neoplasms that
arise from neuroendocrine cells, with Ki-67 immunostaining serving as a crucial biomarker …