BRD4 is well known for its role in super-enhancer organization and transcription activation
of several prominent oncogenes including c-MYC and BCL2. As such, BRD4 inhibitors are …

The tumor suppressor p53 and its homologues, p63 and p73, play a pivotal role in the
regulation of the DNA damage response, cellular homeostasis, development, aging, and …

Simple Summary BRPF1 (also named as BR140) was identified 28 years ago, and it was not
until the past 5 years that its mutations in humans caught increasing attention. Those …

Immune cells can protect against tumor progression by killing cancer cells, while aberrant
expression of the immune checkpoint protein PD‐L1 (programmed death ligand 1) in cancer …

The chromatin-based rule governing the selection and activation of replication origins in
metazoans remains to be investigated. Here we report that NFIB, a member of Nuclear …

Signaling by the transforming growth factor–β (TGF-β) receptors I and II (TβRI/II) and the
primary cilia-localized sonic hedgehog (Shh) pathway promote cell migration and …

The role of O-GlcNAc transferase (OGT) in gene regulation and tumor invasion is poorly
understood. Here, we have identified several previously undiscovered OGT-interacting …

Discovery of small-molecule degraders that activate ubiquitin ligase–mediated
ubiquitination and degradation of targeted oncoproteins in cancer cells has been an elusive …

Myocardial regeneration is the key to the functional recovery of ischemic heart.
Angiogenesis plays a pivotal role in myocardial regeneration by resetting a rejuvenation …

The tumor suppressor ING4 has been shown to be reduced in human HCC. The alteration of
ING4 contributes to HCC progression. However, its effect in HCC and the potential …