Regulation of telomerase by telomeric proteins

A Smogorzewska, T de Lange - Annual review of biochemistry, 2004 - annualreviews.org
▪ Abstract Telomeres are essential for genome stability in all eukaryotes. Changes in
telomere functions and the associated chromosomal abnormalities have been implicated in …

Genetic engineering of filamentous fungi—progress, obstacles and future trends

V Meyer - Biotechnology advances, 2008 - Elsevier
Filamentous fungi are widely used in biotechnology as cell factories for the production of
chemicals, pharmaceuticals and enzymes. In order to improve their productivities, genetic …

A means to a DNA end: the many roles of Ku

JA Downs, SP Jackson - Nature reviews Molecular cell biology, 2004 - nature.com
Ku is of central importance to DNA repair in eukaryotes. In addition, Ku has a key role in a
number of other fundamental cellular processes such as telomere maintenance …

Understanding the molecular pathways associated with seed vigor

L Ventura, M Donà, A Macovei, D Carbonera… - Plant physiology and …, 2012 - Elsevier
Farmers and growers are constantly looking for high quality seeds able to ensure uniform
field establishment and increased production. Seed priming is used to induce pre …

The importance of safeguarding genome integrity in germination and seed longevity

WM Waterworth, CM Bray… - Journal of Experimental …, 2015 - academic.oup.com
Seeds are important to agriculture and conservation of plant biodiversity. In agriculture, seed
germination performance is an important determinant of crop yield, in particular under …

Arabidopsis telomerase takes off by uncoupling enzyme activity from telomere length maintenance in space

BB Barcenilla, AD Meyers, C Castillo-González… - Nature …, 2023 - nature.com
Spaceflight-induced changes in astronaut telomeres have garnered significant attention in
recent years. While plants represent an essential component of future long-duration space …

DNA repair mechanisms in plants: crucial sensors and effectors for the maintenance of genome integrity

CM Bray, CE West - New phytologist, 2005 - Wiley Online Library
As obligate phototrophs, plants harness energy from sunlight to split water, producing
oxygen and reducing power. This lifestyle exposes plants to particularly high levels of …

Ku70 stimulates fusion of dysfunctional telomeres yet protects chromosome ends from homologous recombination

GB Celli, EL Denchi, T de Lange - Nature cell biology, 2006 - nature.com
Ku70–Ku80 heterodimers promote the non-homologous end-joining (NHEJ) of DNA breaks
and, as shown here, the fusion of dysfunctional telomeres. Paradoxically, this heterodimer is …

Functional links between telomeres and proteins of the DNA-damage response

FA di Fagagna, SH Teo, SP Jackson - Genes & development, 2004 - genesdev.cshlp.org
In response to DNA damage, cells engage a complex set of events that together comprise
the DNA-damage response (DDR). These events bring about the repair of the damage and …

Efficient induction of heritable inversions in plant genomes using the CRISPR/Cas system

C Schmidt, M Pacher, H Puchta - The Plant Journal, 2019 - Wiley Online Library
During the evolution of plant genomes, sequence inversions occurred repeatedly making
the respective regions inaccessible for meiotic recombination and thus for breeding …