Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis, an infectious
disease with one of the highest morbidity and mortality rates worldwide. Leveraging its …

Ceramides are bioactive sphingolipids that support the structure of the plasma membrane
and mediate numerous cell-signaling events in eukaryotic cells. The finding that ceramides …

Lipid rafts, also known as microdomains, are important components of cell membranes and
are enriched in cholesterol, glycophospholipids and receptors. They are involved in various …

Macrophages, as professional phagocytes of the immune system, possess the ability to
detect and clear invading pathogens and apoptotic cells through phagocytosis …

Neutrophils readily infiltrate infection foci, phagocytose and usually destroy microbes. In
tuberculosis (TB), a chronic pulmonary infection caused by Mycobacterium tuberculosis …

Abstract Mannose-capped lipoarabinomannan (ManLAM), present in all members of the
Mycobacterium tuberculosis complex and in other pathogenic Mycobacterium spp, is a high …

Mycobacterium tuberculosis (Mtb) is a very successful pathogen, strictly adapted to humans
and the cause of tuberculosis. Its success is associated with its ability to inhibit host cell …

Tuberculosis (TB) is still a severe public health problem; the current diagnostic tests have
limitations that delay treatment onset. Lipoarabinomannan (LAM) is a glycolipid that is a …

Sensitive and specific blood-based assays for the detection of pulmonary and
extrapulmonary tuberculosis would reduce mortality associated with missed diagnoses …

The mycobacterium genus contains a broad range of species, including the human
pathogens M. tuberculosis and M. leprae. These bacteria are best known for their residence …