The ongoing worldwide increase in life expectancy portends a rising prevalence of age-
related cardiovascular (CV) diseases in the coming decades that demands a deeper …

Major advances in preventing, delaying, or curing individual pathologies are responsible for
an increasingly long life span in the developed parts of our planet, and indeed reaching …

This report updates the 2018–19 recommendations of the Advisory Committee on
Immunization Practices (ACIP) regarding the use of seasonal influenza vaccines in the …

Influenza virus infections are a major public health concern and cause significant morbidity
and mortality worldwide. Current influenza virus vaccines are an effective countermeasure …

This report updates the 2015–16 recommendations of the Advisory Committee on
Immunization Practices (ACIP) regarding the use of seasonal influenza vaccines (Grohskopf …

Broadly neutralizing antibodies against highly variable pathogens have stimulated the
design of vaccines and therapeutics. We report the use of diverse camelid single-domain …

Highlights•Aging is associated with a decline in immune function termed 'immune
senescence'.•Effective influenza vaccines need to be developed for better protection the …

Background Immune responses to influenza vaccines decline with age, reducing clinical
effectiveness. We compared the effect of the more immunogenic high-dose trivalent …

Seasonal influenza is a prevalent and serious annual illness resulting in widespread
morbidity and economic disruption throughout the population; the elderly and …

Diabetes mellitus imposes a significant and increasing burden on society, with major
consequences for human health, welfare and the economy worldwide. Persons with …