Abstract Cyclin-dependent kinase 4 (CDK4) and CDK6 are critical mediators of cellular
transition into S phase and are important for the initiation, growth and survival of many …

The 2016 revised fourth edition of the World Health Organization (WHO) classification of
central nervous system (CNS) tumors incorporated molecular features with histologic …

For over three decades, a mainstay and goal of clinical oncology has been the development
of therapies promoting the effective elimination of cancer cells by apoptosis. This …

BACKGROUND Cyclins and cyclin-dependent kinases (CDKs) drive cell division. Of
particular importance to the cancer field are D-cyclins, which activate CDK4 and CDK6. In …

Retrotransposable elements are deleterious at many levels, and the failure of host
surveillance systems for these elements can thus have negative consequences. However …

Cancer is characterized by uncontrolled tumour cell proliferation resulting from aberrant
activity of various cell cycle proteins. Therefore, cell cycle regulators are considered …

Glioblastoma is the most common malignant primary brain tumor in adults and is almost
invariably fatal. Despite our growing understanding of the various mechanisms underlying …

Using an ORF kinome screen in MCF-7 cells treated with the CDK4/6 inhibitor ribociclib plus
fulvestrant, we identified FGFR1 as a mechanism of drug resistance. FGFR1-amplified/ER+ …

Uncontrolled cellular proliferation, mediated by dysregulation of the cell-cycle machinery
and activation of cyclin-dependent kinases (CDKs) to promote cell-cycle progression, lies at …

Cancer represents a pathological manifestation of uncontrolled cell division; therefore, it has
long been anticipated that our understanding of the basic principles of cell cycle control …