We review preclinical and clinical evidences strongly suggesting that memantine, an old
drug currently approved for Alzheimer's dementia, is an effective treatment for acute mania …

Neuropsychiatric disorders involve various pathological mechanisms, resulting in
neurodegeneration and brain atrophy. Neurodevelopmental processes have shown to be …

Bipolar spectrum disorders carry a significant public health burden. Disproportionately high
rates of suicide, incarceration, and comorbid medical conditions necessitate an …

Abstract Background Acetylcholinesterase inhibitors (AceI) and memantine might prove
useful in bipolar disorder (BD) given their neuroprotective and pro-cognitive effects, as …

Memantine in the management of affective recurrences of bipolar disorders after the
discontinuation of long-term lithium treatment: three case histories - Giulia Serra, Lavinia De …

Background: Mania seems to be associated with an increased dopamine (DA) transmission.
Antidepressant treatments can induce mania in humans and potentiated DA transmission in …

This review focuses on new pharmacological agents tested as BD maintenance treatment,
from experimental models until phase 3 clinical trials during the last 5 years, ie from 2010 till …

​ Мемантин—это слабый неконкурентный антагонист магниевого сайта в открытой
конфигурации NMDA—рецепторов с быстрой кинетикой связывания и диссоциации с …

A great deal of evidence suggests that virtually all antidepressant treatments induce a
dopaminergic behavioral supersensitivity. We have suggested that this effect may play a key …

We have recently reported that memantine has a clinically relevant antimanic and long-
lasting mood-stabilizing effect in treatment-resistant bipolar disorders, both as augmenting …