The tightly regulated biosynthesis and catabolism of the glycosaminoglycan hyaluronan, as
well as its role in organizing tissues and cell signaling, is crucial for the homeostasis of …

Cellular microRNAs (miRNAs) are an important class of small, non-coding RNAs that bind to
host mRNAs based on sequence complementarity and regulate protein expression. They …

Development of highly effective, broad-spectrum antiviral agents is the major objective
shared by the fields of virology and pharmaceutics. Antiviral drug development has focused …

This study explored the pathogenesis of human immunodeficiency virus (HIV) and
monkeypox co-infection, identifying candidate hub genes and potential drugs using …

Viruses require host cellular factors for successful replication. A comprehensive systems-
level investigation of the virus-host interactome is critical for understanding the roles of host …

Understanding the molecular mechanisms underlying the pathogenesis of amyotrophic
lateral sclerosis (ALS), a devastating neurodegenerative disease, is a major challenge. We …

Viruses are strictly dependent on cells to propagate and many incorporate host proteins in
their viral particles, but the significance of this incorporation is poorly understood. Recently …

The RNA-dependent RNA polymerase (RdRp) of influenza A virus is a heterotrimeric
complex composed of the PB1, PB2, and PA subunits. The interplay between host factors …

Over the last several years a wealth of transformative human–virus interaction discoveries
have been produced using loss-of-function functional genomics. These insights have greatly …

Background Previously, we showed that the tetraspanin membrane protein CD63 mediates
both early and post-integration stages of the HIV-1 replication cycle. The temporal roles of …