The insulin receptor (IR) gene undergoes differential splicing that generates two IR isoforms,
IR-A and IR-B. The physiological roles of IR isoforms are incompletely understood and …

Gene therapy is at the cusp of a revolution for treating a large spectrum of CNS disorders by
providing a durable therapeutic protein via a single administration. Adeno-associated virus …

Alzheimer's disease (AD) is the most common cause of dementia, yet there is no cure or
diagnostics available prior to the onset of clinical symptoms. Extracellular vesicles (EVs) are …

Recent studies have suggested that physiological and behavioral traits may be
transgenerationally inherited through the paternal lineage, possibly via non-genomic signals …

Toll‐like receptors (TLRs) or pattern recognition receptors respond to pathogen‐associated
molecular patterns (PAMPs) or internal damage‐associated molecular patterns (DAMPs) …

Amyloid plaques in Alzheimer's disease (AD) mice are surrounded by activated microglia.
The functional role of microglia activation in AD is not well understood; both detrimental and …

Neurological disorders–disorders of the brain, spine and associated nerves–are a leading
contributor to global disease burden with a shockingly large associated economic cost …

Insulin-like growth factor 2 (IGF2) emerged as a critical mechanism of synaptic plasticity and
learning and memory. Deficits in IGF2 in the brain, serum, or cerebrospinal fluid (CSF) are …

In the 30 years since the first report of parental imprinting in insulin-like growth factor 2 (Igf2)
knockout mouse models, we have learnt much about the structure of this protein, its role and …

Neural stem cells (NSCs) are found in two regions in the adult brain: the subgranular zone
(SGZ) in the hippocampal dentate gyrus and the subventricular zone (SVZ) adjacent to the …