Ion channels play a central role in the regulation of nearly every cellular process. Dating
back to the classic 1952 Hodgkin–Huxley model of the generation of the action potential, ion …

Despite widespread and striking examples of physiological oscillations, their functional role
is often unclear. Even glycolysis, the paradigm example of oscillatory biochemistry, has seen …

Rationale: Cardiac function is under exquisite intrinsic cardiac neural control. Neuroablative
techniques to modulate control of cardiac function are currently being studied in patients …

Even before the sinoatrial node (SAN) was discovered, cardiovascular science was
engaged in an active investigation of when and why the heart would beat. After the …

Cardiac automaticity is set by pacemaker activity of the sinus node (SAN). In addition to the
ubiquitously expressed cardiac voltage-gated L-type Cav1. 2 Ca2+ channel isoform …

Background: Sinoatrial node cells (SANC) automaticity is generated by functional
association between the activity of plasmalemmal ion channels and local diastolic …

Background The sinoatrial node (SAN) of the heart produces rhythmic action potentials,
generated via calcium signaling within and among pacemaker cells. Our previous work has …

Gastrointestinal (GI) organs display spontaneous, non‐neurogenic electrical, and
mechanical rhythmicity that underlies fundamental motility patterns, such as peristalsis and …

The cardiac cycle starts when an action potential is produced by pacemaking cells in the
sinoatrial node. This cycle is repeated approximately 100 000 times in humans and 1 million …

Hyperpolarization-activated cyclic nucleotide–gated (HCN) channels are the molecular
correlate of the If current and are critically involved in controlling neuronal excitability and …