Precision medicine in human heart modeling: perspectives, challenges, and opportunities
Precision medicine is a new frontier in healthcare that uses scientific methods to customize
medical treatment to the individual genes, anatomy, physiology, and lifestyle of each person …
medical treatment to the individual genes, anatomy, physiology, and lifestyle of each person …
The cardiovascular system: mathematical modelling, numerical algorithms and clinical applications
Mathematical and numerical modelling of the cardiovascular system is a research topic that
has attracted remarkable interest from the mathematical community because of its intrinsic …
has attracted remarkable interest from the mathematical community because of its intrinsic …
[HTML][HTML] A comprehensive and biophysically detailed computational model of the whole human heart electromechanics
While ventricular electromechanics is extensively studied in both physiological and
pathological conditions, four-chamber heart models have only been addressed recently; …
pathological conditions, four-chamber heart models have only been addressed recently; …
Modeling cardiac muscle fibers in ventricular and atrial electrophysiology simulations
Since myocardial fibers drive the electric signal propagation throughout the myocardium,
accurately modeling their arrangement is essential for simulating heart electrophysiology …
accurately modeling their arrangement is essential for simulating heart electrophysiology …
[图书][B] Mathematical modelling of the human cardiovascular system: data, numerical approximation, clinical applications
Mathematical and numerical modelling of the human cardiovascular system has attracted
remarkable research interest due to its intrinsic mathematical difficulty and the increasing …
remarkable research interest due to its intrinsic mathematical difficulty and the increasing …
[HTML][HTML] 3D–0D closed-loop model for the simulation of cardiac biventricular electromechanics
Two crucial factors for accurate numerical simulations of cardiac electromechanics, which
are also essential to reproduce the synchronous activity of the heart, are:(i) accounting for …
are also essential to reproduce the synchronous activity of the heart, are:(i) accounting for …
Personalized cardiac computational models: from clinical data to simulation of infarct-related ventricular tachycardia
A Lopez-Perez, R Sebastian, M Izquierdo… - Frontiers in …, 2019 - frontiersin.org
In the chronic stage of myocardial infarction, a significant number of patients develop life-
threatening ventricular tachycardias (VT) due to the arrhythmogenic nature of the remodeled …
threatening ventricular tachycardias (VT) due to the arrhythmogenic nature of the remodeled …
[HTML][HTML] The role of mechano-electric feedbacks and hemodynamic coupling in scar-related ventricular tachycardia
Abstract Mechano-electric feedbacks (MEFs), which model how mechanical stimuli are
transduced into electrical signals, have received sparse investigation by considering …
transduced into electrical signals, have received sparse investigation by considering …
Generating Purkinje networks in the human heart
The Purkinje network is an integral part of the excitation system in the human heart. Yet, to
date, there is no in vivo imaging technique to accurately reconstruct its geometry and …
date, there is no in vivo imaging technique to accurately reconstruct its geometry and …
Modeling our understanding of the His-Purkinje system
EJ Vigmond, BD Stuyvers - Progress in biophysics and molecular biology, 2016 - Elsevier
Abstract The His-Purkinje System (HPS) is responsible for the rapid electric conduction in
the ventricles. It relays electrical impulses from the atrioventricular node to the muscle cells …
the ventricles. It relays electrical impulses from the atrioventricular node to the muscle cells …