The interaction between histones and DNA is important for eukaryotic gene expression. A
loose interaction caused, for example, by the neutralization of a positive charge on the …

Exercise is fundamental for good health, whereas physical inactivity underpins many chronic
diseases of modern society. It is well appreciated that regular exercise improves metabolism …

Epigenetic aberrations, which are recognized as key drivers of several human diseases, are
often caused by genetic defects that result in functional deregulation of epigenetic proteins …

The onset of heart failure is typically preceded by cardiac hypertrophy, a response of the
heart to increased workload, a cardiac insult such as a heart attack or genetic mutation …

Epigenetic enzymes are often dysregulated in human tumors through mutation, altered
expression, or inappropriate recruitment to certain loci. The identification of these enzymes …

Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …

Histone deacetylases (HDACs) are part of a vast family of enzymes that have crucial roles in
numerous biological processes, largely through their repressive influence on transcription …

Transcriptional regulation in eukaryotes occurs within a chromatin setting, and is strongly
influenced by the post-translational modification of histones, the building blocks of …

Histone deacetylases (HDACs) are enzymes involved in the remodelling of chromatin, and
have a key role in the epigenetic regulation of gene expression. In addition, the activity of …

Reversible acetylation of histone and non-histone proteins is one of the most abundant post-
translational modifications in eukaryotic cells. Protein acetylation and deacetylation are …