Signaling pathways and targeted therapies for psoriasis

J Guo, H Zhang, W Lin, L Lu, J Su… - Signal Transduction and …, 2023 - nature.com
Psoriasis is a common, chronic, and inflammatory skin disease with a high burden on
individuals, health systems, and society worldwide. With the immunological pathologies and …

A route for investigating psoriasis: from the perspective of the pathological mechanisms and therapeutic strategies of cancer

X Wu, Y Ma, L Wang, X Qin - International Journal of Molecular Sciences, 2023 - mdpi.com
Psoriasis is an incurable skin disease that develops in about two-thirds of patients before the
age of 40 and requires lifelong treatment; its pathological mechanisms have not been fully …

DNMT inhibitor, 5-aza-2′-deoxycytidine mitigates di (2-ethylhexyl) phthalate-induced aggravation of psoriasiform inflammation in mice via reduction in global DNA …

AS Alfardan, A Nadeem, SF Ahmad, NO Al-Harbi… - International …, 2024 - Elsevier
Psoriasis is classified as an autoimmune disorder characterized by abnormal immune
response leading to the development of chronic dermal inflammation. Most individuals have …

Upregulated miR-374a-5p drives psoriasis pathogenesis through WIF1 downregulation and Wnt5a/NF-κB activation

J Ma, L Gan, H Chen, L Chen, Y Hu, C Luan, K Chen… - Cellular …, 2024 - Elsevier
Background Psoriasis is a chronic, inflammatory skin disease. MicroRNAs (miRNAs) are an
abundant class of non-coding RNA molecules. Recent studies have shown that multiple …

Regulation of Follicular Development in Chickens: WIF1 Modulates Granulosa Cell Proliferation and Progesterone Synthesis via Wnt/β-Catenin Signaling Pathway

R Nie, W Zhang, H Tian, J Li, Y Ling, B Zhang… - International Journal of …, 2024 - mdpi.com
Proliferation, apoptosis, and steroid hormone secretion by granulosa cells (GCs) and theca
cells (TCs) are essential for maintaining the fate of chicken follicles. Our previous study …

[HTML][HTML] The New Era of Immune Skin Diseases: Exploring Advances in Basic Research and Clinical Translations

B Zhang, X Mei, M Zhao, Q Lu - Journal of Translational Autoimmunity, 2024 - Elsevier
As a vital immune organ, skin performs multiple physiological functions. Immune skin
diseases (ISDs), characterized by dysregulated immune responses, manifested as abnormal …