The 'Lambeth Conventions' is a guidance document, written in 1987 (Walker et al., 1988),
intended to be of practical value in the investigation of experimental arrhythmias induced by …

The isolated perfused mammalian heart preparation was established in 1897 by Oscar
Langendorff. The method was developed on the basis of the isolated perfused frog heart …

The cardiac inward rectifier potassium current (IK1), present in all ventricular and atrial
myocytes, has been suggested to play a major role in repolarization of the action potential …

The generation of human cardiomyocytes (CMs) from human pluripotent stem cells (hPSCs)
has become an important resource for modeling human cardiac disease and for drug …

Voltage gated ion channels are central in defining the fundamental properties of the
ventricular cardiac action potential (AP), and are also involved in the development of drug …

The isolated perfused heart has been used increasingly during the last decade as a model
for identifying actions of drugs on ventricular fibrillation (VF) induced by myocardial …

Species and Drug‐Induced Long APD and EADs. Introduction: Although isolated Purkinje
fibers (PFs) often are used to evaluate the electrophysiologic effects of new drugs in terms of …

The Molecular and Ionic Specificity of Antiarrhythmic Drug Actions. Virtually all clinical
antiarrhythmic agents act by reducing ion channel conductance, with sodium (Na+) …

Cardiac K+ channels are cardiomyocyte membrane proteins that regulate K+ ion flow across
the cell membrane on the electrochemical gradient and determine the resting membrane …

OBJECTIVES.: This clinical study was designed to compare rate-dependent effects of class
III agents on QT prolongation. BACKGROUND.: Clinical data that compare the …