Levetiracetam mechanisms of action: from molecules to systems

IJ Contreras-García, N Cárdenas-Rodríguez… - Pharmaceuticals, 2022 - mdpi.com
Epilepsy is a chronic disease that affects millions of people worldwide. Antiepileptic drugs
(AEDs) are used to control seizures. Even though parts of their mechanisms of action are …

Selenium nanoparticles and metformin ameliorate streptozotocin-instigated brain oxidative-inflammatory stress and neurobehavioral alterations in rats

AP Ebokaiwe, S Okori, JO Nwankwo… - Naunyn-Schmiedeberg's …, 2021 - Springer
Selenium nanoparticles (SeNPs) are well reported to exhibit pharmacological activities both
in vitro and in vivo. However, literature is devoid of studies on the impact of SeNPs and/or …

Protocatechuic acid ameliorates neurobehavioral deficits via suppression of oxidative damage, inflammation, caspase-3 and acetylcholinesterase activities in diabetic …

IA Adedara, OB Fasina, MF Ayeni, OM Ajayi… - Food and chemical …, 2019 - Elsevier
Clinical and experimental data have demonstrated that diabetes is associated with
neurological complications. Protocatechuic acid (PCA) is a phenolic phytochemical widely …

Alteration of oxidative stress and inflammatory cytokines induces apoptosis in diabetic nephropathy

J Sha, B Sui, X Su, Q Meng… - Molecular Medicine …, 2017 - spandidos-publications.com
Diabetic nephropathy (DN) is one of the most significant long‑term complications in terms of
morbidity and mortality for diabetic patients; however, the exact cause remains unknown. To …

Protective effects of methanolic extract of Juglans regia L. leaf on streptozotocin-induced diabetic peripheral neuropathy in rats

D Nasiry, AR Khalatbary, H Ahmadvand… - … and alternative medicine, 2017 - Springer
Background Oxidative stress has a pivotal role in the pathogenesis and development of
diabetic peripheral neuropathy (DPN), the most common and debilitating complications of …

Levetiracetam attenuates diabetes-associated cognitive impairment and microglia polarization by suppressing neuroinflammation

Y Zhang, L Wang, H Guo, T Han, Y Chang… - Frontiers in …, 2023 - frontiersin.org
Introduction: Cognitive impairment is a common complication and comorbidity of diabetes.
However, the underlying mechanisms of diabetes-associated cognitive dysfunction are …

Electroacupuncture may alleviate diabetic neuropathic pain by inhibiting the microglia P2X4R and neuroinflammation

S Qu, H Wang, Q Hu, Y Ma, Y Kang, L Ma, X Li… - Purinergic …, 2023 - Springer
Diabetic neuropathic pain (DNP) is a common and destructive complication of diabetes
mellitus. The discovery of effective therapeutic methods for DNP is vitally imperative …

[HTML][HTML] Autism spectrum disorder and the TGF-beta signalling pathway: Molecular relationships and therapeutic possibilities

A Demirezen, O Erbaş - Demiroglu Science University Florence …, 2023 - journaltxdbu.com
Autism spectrum disorder (ASD), a neurodevelopmental condition, is defined by challenges
in social interaction and communication, repetitive behaviors, and focused or limited …

Dorsal root ganglia P2X4 and P2X7 receptors contribute to diabetes-induced hyperalgesia and the downregulation of electroacupuncture on P2X4 and P2X7

Q Hu, X He, Y Ma, L Ma, S Qu, H Wang, Y Kang… - Purinergic …, 2023 - Springer
Diabetic neuropathic pain (DNP) is highly common in diabetes patients. P2X receptors play
critical roles in pain sensitization. We previously showed that elevated P2X3 expression in …

Bamboo leaf extract ameliorates diabetic nephropathy through activating the AKT signaling pathway in rats

C Ying, Y Mao, L Chen, S Wang, H Ling, W Li… - International journal of …, 2017 - Elsevier
Diabetic nephropathy (DN) is one of the most severe diabetic complication and it is
becoming become a worldwide epidemic, accounting for approximately one-third of all case …