Herein we summarize important discoveries made over many years about Leydig cell
function and regulation. Fetal Leydig cells produce the high levels of androgen (testosterone …

▪ Abstract Steroid hormone biosynthesis is acutely regulated by pituitary trophic hormones
and other steroidogenic stimuli. This regulation requires the synthesis of a protein whose …

Steroidogenic Factor 1: A Key Determinant of Endocrine Development and Function | Endocrine
Reviews | Oxford Academic Skip to Main Content Advertisement Oxford Academic Journals …

Steroid hormones regulate essential physiological processes and inadequate levels are
associated with various pathological conditions. Consequently, the process of steroid …

In blood coagulation, units of the protein fibrinogen pack together to form a fibrin clot, but a
crystal structure for fibrinogen is needed to understand how this is achieved. The structure of …

Nuclear receptors are intracellular proteins that act as transcription factors. Proteins with
classic nuclear receptor domain structure lacking identified signaling ligands are designated …

Expression of the genes that mediate the first steps in steroidogenesis, the steroidogenic
acute regulatory protein (STARD1), the cholesterol side-chain cleavage enzyme …

Although it is well established that the circadian clock regulates mammalian reproductive
physiology, the molecular mechanisms by which this regulation occurs are not clear. The …

Mutations in the DAX-1 gene are responsible for congenital X-linked adrenal hypoplasia, a
disease that is associated with hypogonadotropic hypogonadism,. DAX-1 expression is …

17α-Hydroxylase (CYP17) expression in propagated theca cells isolated from the ovaries of
women with polycystic ovary syndrome (PCOS) is persistently elevated, compared with …