Homeostasis in healthy tissues strongly relies on cell-to-cell adhesion and cell-to-
extracellular matrix interactions. For instance, normal epithelial cells maintain tissue …

Protein post-translational modification (PTM) is a covalent process that occurs in proteins
during or after translation through the addition or removal of one or more functional groups …

Metastasis is the leading cause of death for colorectal cancer (CRC) patients, and the
spreading tumor cells adhesion to endothelial cells is a critical step for extravasation and …

Correlative clinical evidence and experimental observations indicate that integrin adhesion
receptors, in particular those of the αV family, are relevant to cancer cell features, including …

Cells adhere to one another and/or to matrices that surround them. Regulation of cell–cell
(intercellular) and cell–matrix adhesion is tightly controlled in normal cells, however, defects …

Inflammation is a protective response of the body potentially caused by microbial, viral, or
fungal infections, tissue damage, or even autoimmune reactions. The cardinal signs of …

Typically the normal epithelial cells are a single layer, held tightly by adherent proteins that
prevent the mobilization of the cells from the monolayer sheet. During prostate cancer …

E-cadherin and P-cadherin are major contributors to cell–cell adhesion in epithelial tissues,
playing pivotal roles in important morphogenetic and differentiation processes during …

The progression of colorectal carcinoma (CRC) to invasive and metastatic disease may
involve localized occurrences of epithelial-mesenchymal transition (EMT). However …

Chemotherapeutic drugs target a physiological differentiating feature of cancer cells as they
tend to actively proliferate more than normal cells. They have well-known side-effects …