Centella asiatica (also known as Centella asiatica (L.) Urb. or Gotu kola) is a traditional
Chinese medicine with extensive medicinal value, which is commonly used in Southeast …

Diffuse myocardial fibrosis resulting from the excessive deposition of collagen fibres through
the entire myocardium is encountered in a number of chronic cardiac diseases. This lesion …

Aims Heart failure with preserved ejection fraction (HFpEF) is a multifactorial disease that
constitutes several distinct phenotypes, including a common cardiometabolic phenotype …

Cardiovascular (CV) disease and cancer are the leading causes of death., Over the last
decades, it has been appreciated that both CV disease and cancer are more common in …

Disease progression is usually accompanied by changes in the biochemical composition of
cells and tissues and their biophysical properties. For instance, hallmarks of cancer include …

Objective: This study aimed to explore the role of circular RNAs (circRNAs) in M2
macrophage (M2M)-derived small extracellular vesicles (SEVs) in myocardial fibrosis …

Myocardial fibrosis is a remodeling process of the extracellular matrix (ECM) following
cardiac stress.“Replacement fibrosis” is a term used to describe wound healing in the acute …

The term 'mechanosensation'describes the capacity of cells to translate mechanical stimuli
into the coordinated regulation of intracellular signals, cellular function, gene expression …

Research about heart failure (HF) has made major progress in the last years. We give here
an update on the most recent findings. Landmark trials have established new treatments for …

Myocardial fibrosis represents the primary pathological change associated with diabetic
cardiomyopathy and heart failure, and it leads to decreased myocardial compliance with …