Gene therapy is at the cusp of a revolution for treating a large spectrum of CNS disorders by
providing a durable therapeutic protein via a single administration. Adeno-associated virus …

The endocannabinoid (eCB) system has attracted attention for its role in various behavioral
and brain functions, and as a therapeutic target in neuropsychiatric disease states, including …

Capsaicin, the pungent ingredient in chili peppers, produces intense burning pain in
humans. Capsaicin selectively activates the transient receptor potential vanilloid 1 (TRPV1) …

Adeno-associated virus serotype 9 (AAV9)-mediated gene transfer has been reported in
central nervous system (CNS) and peripheral tissues. The current study compared the …

Advances in genome sequencing have greatly facilitated the identification of genomic
variants underlying rare neurodevelopmental and neurodegenerative disorders …

Transient receptor potential vanilloid type 1 (TRPV1) is highly expressed on sensory
neurons where it serves as a polymodal receptor for detecting physical and chemical stimuli …

Neuropathic pain caused by lesions to somatosensory neurons due to injury or disease is a
widespread public health problem that is inadequately managed by small-molecule …

Although peripheral nerve system has intrinsic regeneration potential, recovery from
peripheral nerve injury (PNI) is often far from optimal, leading to partial or complete loss of …

Introduction: Adeno-associated viral (AAV) vector-mediated gene delivery to the spinal cord
has finally entered the pathway towards regulatory approval. Phase 1 clinical trials using …

N-glycanase 1 (NGLY1) Deficiency is a progressive, ultra-rare, autosomal recessive
disorder with no approved therapy and five core clinical features: severe global …